角质细胞脂质包膜的形成  

Formation of corneocyte lipid envelope

作　　者：李银玲 林万华[1] LI Yinling;LIN Wanhua(Guangxi Universities Key Laboratory of Stem Cell and Biopharmaceutical Technology,Guangxi Normal University,School of Life Sciences,Guangxi Normal University,Guilin 541006,China)

机构地区：[1]广西师范大学生命科学学院,广西高校干细胞与医药生物技术重点实验室,桂林541006

出　　处：《生命的化学》2020年第8期1235-1242,共8页Chemistry of Life

基　　金：国家自然科学基金项目(31560248);广西自然科学基金项目(2016GXNSFAA380176)。

摘　　要：表皮特别是其最外层的角质层是陆生脊椎动物防止失水、抵御外来物质和有害病原体的关键屏障。神经酰胺是这些高度有序的细胞间层状结构的主要成分之一。角质细胞脂质包膜(cornified lipid envelope,CLE)主要由衍生自超长链(ultra-long chain,ULC)-神经酰胺组成,该结构对构建和维持皮肤屏障的完整性起着至关重要的作用。本文综述了表皮神经酰胺的合成、代谢和运输过程,特别是ULC-酰基神经酰胺和CLE形成的过程。对表皮神经酰胺和CLE形成过程的研究有助于阐明鱼鳞病的发病机理,为鱼鳞病的治疗提供线索。The epidermis,especially its outermost stratum corneum,is a key barrier for terrestrial vertebrates to prevent dehydration and resist foreign substances and harmful pathogens.Ceramide is one of the main components of these highly ordered interlaminar structures.Ceramides are the main components of these highly ordered intercellular-layered structures.Corneocyte lipid envelope(CLE)is mainly composed of ultra-long chain(ULC)-acylceramides,which is essential for the construction and maintenance of skin barrier integrity.In this review,we mainly clarified the synthesis,metabolism and transportation of epidermal ceramides,especially the formation of ULC-acylceramides and CLE.The study on the formation process of epidermal ceramide and CLE is helpful to clarify the pathogenesis of ichthyosis and provide clues for effective therapy for ichthyosis.

关 键 词：角质细胞脂质包膜 酰基神经酰胺 神经酰胺 鱼鳞病 

分 类 号：R758.52[医药卫生—皮肤病学与性病学]