肝脏内源性硫化氢代谢和功能  

Endogenous hydrogen sulfide metabolism and function in liver

作　　者：徐文静 XU Wenjing(Department of Pathology,Xi'an Medical University,Xi'an 710021,China)

机构地区：[1]西安医学院基础医学部病理教研室,西安710021

出　　处：《生命的化学》2020年第8期1289-1297,共9页Chemistry of Life

基　　金：国家自然科学基金项目(81860111)。

摘　　要：作为气体信号分子,硫化氢参与了多种生理和病理过程。内源性硫化氢主要由胱硫醚γ-裂合酶(CSE)、胱硫醚β-合酶(CBS)和3-巯基丙酮酸转硫酶(MPST)催化产生,这三种酶在肝脏中均有表达并催化产生硫化氢参与调节肝脏的代谢功能。硫化氢参与肝脏功能调节,包括调节葡萄糖和脂质的代谢、缓解氧化应激和炎症,并且在多种肝脏疾病,如非酒精性脂肪肝、非酒精性脂肪性肝炎、肝癌等的病理生理过程中发挥了保护性作用。本文综述了硫化氢在肝脏中的生物合成和调节代谢过程,并探讨了硫化氢在三种肝脏疾病中的作用和机制。Hydrogen sulfide(H2S)is the most recently recognized gasotransmitter,influencing variety of physiological and pathological processes.Enzymatic production of H2S is catalyzed by cystathionineγ-lyase(CSE),cystathionineβ-synthase(CBS),and 3-mercaptopyruvate sulfurtransferase(MPST).All these three enzymes present in the liver and regulate liver functions via H2S production.H2S is involved in many hepatic functions,including the regulation of glucose and lipid metabolism,alleviat oxidative stress,inflammation,and H2S contributes to the pathogenesis in numbers of liver diseases,such as nonalcoholic fatty liver disease,nonalcoholic steatohepatitis,liver cancer.In this review,the biosynthesis and metabolism of H2S in the liver are summarized and the role of H2S in live disease are further discussed.

关 键 词：硫化氢 非酒精性脂肪肝 非酒精性肝炎 肝癌 

分 类 号：R575[医药卫生—消化系统]