CD4^+T细胞亚群在子宫内膜癌中的研究进展  

Research Progress of CD4^+T Cell Subsets in Endometrial Cancer

作　　者：张凯[1] 刘玉林 胡佳丽 滕飞[1] 薛凤霞(审校)[1] ZHANG Kai;LIU Yu-lin;HU Jia-li;TENG Fei;XUE Feng-xia(Department of Obstetrics and Gynecology,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院妇产科,300052

出　　处：《国际妇产科学杂志》2020年第5期525-530,I0001,共7页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81772790,81802617)。

摘　　要：子宫内膜癌是女性生殖系统中常见的三大恶性肿瘤之一,其发病机制除涉及多因素、多阶段的复杂生物过程,以及长期无孕激素拮抗的雌激素刺激子宫内膜发生恶变外,还与人体免疫系统的异常改变密切相关。而近年肿瘤免疫在子宫内膜癌的研究中仍是一个热点话题,其中CD4^+T淋巴细胞作为肿瘤免疫应答的主要参与者,被分为一系列多功能的免疫细胞亚群,包括1型辅助性T细胞、2型辅助性T细胞、17型辅助性T细胞和调节性T细胞,以及近年新发现的9型辅助性T细胞和22型辅助性T细胞。CD4^+T细胞亚群的分化调节、免疫功能与多种肿瘤的发病机制和肿瘤患者预后密切相关,各亚群细胞数量及分泌的细胞因子的失衡又会促进多种肿瘤的恶性进展。然而,CD4^+T细胞亚群及细胞因子在子宫内膜癌中的研究尚处于起步阶段。本文就近年CD4^+T细胞亚群在子宫内膜癌中的作用加以综述。Endometrial cancer is one of the three most common malignant tumors in the female reproductive system.Its pathogenesis involves not only complex biological processes of multiple factors and stages,but also malignant transformation of endometrium stimulated by estrogen without progesterone antagonism for a long time.It is also closely related to abnormal changes of human immune system.Recently,research on tumor immunity has become a hot topic in the mechanism of the endometrial cancer.CD4^+T lymphocyte cells,as the main participants in the immune response,are divided into a series of multi-functional immune cell subsets,including helper cells T1,helper cells T2,helper cells T17,and regulatory T cells,and helper cell T9 and T22 have been newly discovered in recent years.The differentiation regulation and immune function of CD4^+T cell subsets are closely related to the pathogenesis of various tumors and the prognosis of the patients with tumor.Furthermore,the imbalance of cell number and cytokines secreted by each subgroup will promote the progression of many kinds of tumors.However,the research of CD4^+T cell subsets and their cytokines in endometrial cancer is still in the initial stage.This article reviews the role of CD4^+T cell subsets in endometrial cancer in recent years.

关 键 词：子宫内膜肿瘤 TH1细胞 TH2细胞 TH17细胞 T淋巴细胞 调节性 T淋巴细胞亚群 细胞分化 细胞增殖 

分 类 号：R737.33[医药卫生—肿瘤]