Structural and functional properties of SARS-CoV-2 spike protein:potential antivirus drug development for COVID-19  

作　　者：Yuan Huang Chan Yang Xin-feng Xu Wei Xu Shu-wen Liu 

机构地区：[1]Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China [2]State Key Laboratory of Organ Failure Research,Southern Medical University,Guangzhou 510515,China

出　　处：《Acta Pharmacologica Sinica》2020年第9期1141-1149,共9页中国药理学报（英文版）

基　　金：This project was supported by grants from Guangzhou Science and Technology Program(#201803040006 to WX);the Fund of Natural Science Foundation of Guangdong Province(#2018A030313056 to WX);grants from Major Scientific and Technological Projects of Guangdong Province(#2019B020202002 to SWL).

摘　　要：Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world.It is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The spike(S)protein of SARS-CoV-2,which plays a key role in the receptor recognition and cell membrane fusion process,is composed of two subunits,S1 and S2.The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2,while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain.In this review,we highlight recent research advance in the structure,function and development of antivirus drugs targeting the S protein.

关 键 词：SARS-CoV-2 virus spike protein antivirus drugs ANTIBODIES fusion inhibitors host proteases inhibitors 

分 类 号：R563.1[医药卫生—呼吸系统] R91[医药卫生—内科学]