前列腺肉瘤8例报告并文献复习  

PROSTATE SARCOMA:A REPORT OF 8 CASES AND LITERATURE REVIEW

作　　者：孙照勇 张桂铭[1] 刘勇[1] SUN Zhaoyong;ZHAN Guiming;LIU Yong(Department of Urology,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院泌尿外科,山东青岛266003

出　　处：《青岛大学学报（医学版）》2020年第6期745-746,共2页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金青年科学基金项目(81502195)。

摘　　要：目的探讨前列腺肉瘤的临床特点、诊断和治疗措施。方法回顾性分析经前列腺穿刺活检病理证实为前列腺肉瘤病人8例的临床资料。结果 8例病人均因进行性排尿困难入院,其中1例伴排便困难,1例伴尿潴留。3例病人仅行前列腺根治性切除术;3例病人行根治性膀胱、前列腺切除术加双输尿管皮肤造瘘术,其中2例术后行化疗,1例术后行放疗和化疗;1例行经尿道前列腺电切术(姑息);1例经前列腺穿刺活检确诊后行辅助化疗。前列腺穿刺活检病理检查显示,平滑肌肉瘤6例,横纹肌肉瘤1例,纤维肉瘤1例。8例病人全部获得随访,随访时间2~20个月,平均10个月。8例病人均因肿瘤进展、复发或转移死亡。结论 前列腺肉瘤恶性程度高,无明显临床表现,确诊依赖于病理活检和免疫组化,治疗以根治性手术切除为主,术后辅助放化疗。ObjectiveTo investigate the clinical features,diagnosis,and treatment of prostate sarcoma,and to improve the diagnosis and treatment of prostate sarcoma.MethodsA retrospective analysis was performed for the clinical data of 8 patients with prostate sarcoma confirmed by prostate biopsy in our department.ResultsAll patients were admitted to the hospital due to progressive dysuria,among whom 1 had difficult defecation and 1 had urinary retention.Of all patients,3 underwent radical prostatectomy alone;3 underwent radical cystectomy,prostatectomy,and bilateral cutaneous ureterostomy,among whom 2 received chemotherapy after surgery and 1 received radiotherapy and chemotherapy after surgery;1 underwent transurethral resection of the prostate(palliative treatment);1 underwent adjuvant chemotherapy after confirmed diagnosis based on prostate biopsy.Prostate biopsy showed leiomyosarcoma in 6 patients,rhabdomyosarcoma in 1 patient,and fibrosarcoma in 1 patient.All 8 patients were followed up for 2 to 20 months,with a mean follow-up time of 10 months.All patients died due to tumor progression,recurrence,or metastasis.ConclusionProstate sarcoma is a rare malignant tumor with high malignancy and has no obvious clinical manifestations.The diagnosis of this disease depends on pathological biopsy and immunohistochemistry.Radical surgical resection combined with postoperative adjuvant chemoradiotherapy is the main treatment method.

关 键 词：前列腺肿瘤 肉瘤 诊断 治疗学 预后 

分 类 号：R737.25[医药卫生—肿瘤]