miR-206在人类肿瘤发展中的作用及其机制研究  

Mechanism of miR-206 in the development of human tumors

作　　者：王茂林 胡建宏[1] 潘亚文[2] Wang Mao-lin;Hu Jian-hong;Pan Ya-wen(Institute of Neurosurgery,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Neurosurgery,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院神经外科研究所,甘肃兰州730030 [2]兰州大学第二医院神经外科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2020年第5期79-83,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金重点项目(18JR3RA365)。

摘　　要：肿瘤的发生是一个复杂、多步骤的过程,微小RNA可能在人类肿瘤的发生和发展过程中发挥重要作用。miR-206是一条长度为21个核苷酸的单链非编码RNA,其在转录后水平通过降解信使RNA或抑制蛋白质翻译的方式调控靶基因,从而参与细胞内多种生物学过程。随着对miR-206研究的不断深入,发现其不仅在骨骼肌中存在表达,且在其他多个脏器(如肺脏、心脏和脑等)以及多种肿瘤(如乳腺癌、卵巢癌、胃癌、胶质瘤等)组织中也异常表达,并参与调控这些肿瘤的发生及发展过程。Tumorogenesis is a complex and multi-step process.MicroRNAs may play an important role in the occurrence and development of human tumors.miR-206 is a 21-nucleotide single-stranded non-coding small RNA,negatively regulating target genes at the post-transcriptional level by degrading messenger RNA(mRNA)or inhibiting protein translation.With the development of the research on miR-206,it has been found that miR-206 is not only expressed in skeletal muscle,but also in many other organs(such as lung,heart and brain)and various tumors(such as breast cancer,ovarian cancer,gastric cancer,glioma and so on),and participates in regulating the processes of these tumors.

关 键 词：miR-206 肿瘤 靶向治疗 

分 类 号：R730.4[医药卫生—肿瘤]