健脾解毒汤联合西药治疗脾胃气虚型复发性口腔溃疡临床研究  

Clinical Study on Jianpi Jiedu Tang Combined with Western Medicine for Recurrent Oral Ulcer of Spleen-Stomach Qi Deficiency Type

作　　者：黄仲良 HUANG Zhongliang

机构地区：[1]绍兴市中心医院口腔科,浙江绍兴312030

出　　处：《新中医》2020年第19期105-107,共3页New Chinese Medicine

摘　　要：目的:观察健脾解毒汤联合西医治疗脾胃气虚型复发性口腔溃疡(ROU)的临床效果。方法:将符合研究标准的90例ROU患者随机分为西医组和联合组,2组各45例。西医组给予地塞米松和维生素B1、B2、C等常规治疗,联合组在常规西医治疗基础上自拟健脾解毒汤治疗,均持续治疗2~3个疗程并随访6个月。比较2组治疗后溃疡愈合时间、疼痛视觉模拟评分法(VAS)、中医症状积分及随访复发率情况,评估临床治疗效果和安全性。结果:联合组愈合时间短于西医组(P<0.05),2组治疗后VAS评分、中医症状积分均有降低(P<0.05);与西医组比较,联合组治疗后VAS评分、中医症状积分偏低,差异有统计学意义(P<0.05)。联合组和西医组总有效率分别为95.56%、80.00%,组间比较,差异有统计学意义(P<0.05)。2组随访3个月复发率比较,差异无统计学意义(P>0.05);联合组随访6个月复发率低于西医组,差异有统计学意义(P<0.05)。2组治疗期间均未见明显不良反应,安全性较好。结论:从中西医结合角度治疗ROU,可有效缩短溃疡愈合时间、减轻疼痛和减少复发,且安全性好,临床疗效显著。Objective:To observe the clinical effect of Jianpi Jiedu tang combined with western medicine for recurrent oral ulcer(ROU) of spleen-stomach qi deficiency type. Methods: A total of 90 cases of ROU patients who met the study criteria were randomly divided into the western medicine group and the combination group, 45 cases in each group. The western medicine group was given dexamethasone and vitamin B1, B2 and C and other routine treatment, and the combination group was additionally treated with self-made Jianpi Jiedu tang based on routine western medicine treatment.Both groups were treated for two to three courses and followed up for six months. After treatment, the healing time of ulcer, the scores of Visual Analogue Scale(VAS) and Chinese medicine symptoms as well as recurrence rates in the two groups were compared;the clinical effect and safety were evaluated. Results:The healing time in the combination group was shorter than that in the western medicine group(P<0.05). After treatment, the scores of VAS and Chinese medicine symptoms in the two groups were decreased(P<0.05). Compared with those in the western medicine group,the scores of VAS and Chinese medicine symptoms in the combination group after treatment were lower,the difference being significant(P<0.05). The total effective rate was 95.56% in the combination group and 80.00% in the western medicine group,the difference being significant(P<0.05). There was no significant difference being found in the comparison of the recurrence rates after three-month follow-up between the two groups(P>0.05),and the recurrence rate in the combination group after six-month follow-up was lower than that in the western medicine group,the difference being significant(P<0.05). There was no obvious adverse reaction in the two groups during the treatment, and the safety was good. Conclusion: The treatment of ROU from the perspective of integrated Chinese and western medicine can effectively shorten the healing time of ulcer,relieve pain and reduce the recurrence,with good safe

关 键 词：复发性口腔溃疡 脾胃气虚型 健脾解毒汤 中医证候积分 复发 

分 类 号：R781.5[医药卫生—口腔医学]