转移前生态位细胞转变过程与抗转移药物开发  

Transformation Process of Cells in Pre-metastasis Niche and Development of Anti-metastatic Drugs

作　　者：于维虹 罗晨[1] 王旻[1] YU Weihong;LUO Chen;WANG Min(School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211198

出　　处：《药学进展》2020年第8期621-628,共8页Progress in Pharmaceutical Sciences

摘　　要：肿瘤转移是导致癌症患者死亡的主要原因。研究发现肿瘤发生转移前会在靶器官建立转移前生态位,为转移的肿瘤细胞提供适合和支持其定植的微环境。转移前生态位的建立涉及信号的传递和响应。原发肿瘤释放信号分子,直接或间接地改变靶器官部位细胞的行为,进而细胞分泌黏附因子、炎性因子、基质金属蛋白酶等,最终形成利于转移细胞定植的生态位。从细胞响应信号发生转变的角度,概述转移前生态位的建立过程,重点概括髓源性抑制细胞、中性粒细胞、巨噬细胞、驻留细胞及基质细胞响应信号分子发生转变的过程及相关机制,并探讨这一细胞转变过程在抗转移药物开发方面的应用价值。Metastasis is the main reason leading to the death of cancer patients.Previous studies have found that tumors can establish a pre-metastatic niche in the target organ before metastasis,which provides a supportive and suitable microenvironment for metastasizing cells to colonize.The formation of the pre-metastatic niche involves signal transmission and response.The primary tumor releases signal molecules,which directly or indirectly cause changes in biological behavior of cells of the targeted organ,thus leading to cells secretion of adhesion factors,inflammatory factors and matrix metalloproteinases,etc.,and finally forming the niche that facilitates colonization of metastatic cells.This review outlines the establishment process of pre-metastatic niche in the view of cellular transformation response to signal molecules,with particular focus on the transformation process and mechanisms of myeloid-derived suppressor cells,neutrophils,macrophages,resident cells and stromal cells,and further exploration of the application value of this cell transformation process in the development of anti-metastatic drugs.

关 键 词：转移前生态位 信号分子 细胞行为变化 抗转移药物 

分 类 号：R73-37[医药卫生—肿瘤]