以铂类为主化疗方案联合调强放射治疗复发性晚期卵巢癌临床观察  

Efficacy of platinum-based chemotherapy combined with IMRT in treatment of recurrent advanced ovarian cancer

作　　者：王晓宏[1] 韩振坤[1] WANG Xiao-hong;HAN Zhen-kun(Department of Radiotherapy,First Affiliated Hospital of Henan Unizoersity of Science and Technology,Luoyang 471000,P.R.Chinsa)

机构地区：[1]河南科技大学第一附属医院放疗科,河南洛阳471000

出　　处：《社区医学杂志》2020年第13期934-937,共4页Journal Of Community Medicine

摘　　要：目的卵巢癌是导致女性死亡的重要恶性肿瘤,多数患者就诊时已处于晚期,丧失手术治疗时机,故临床寻求一种高效的治疗方式对改善患者生存质量具有重要意义。本研究探讨以铂类为主化疗方案联合调强放射治疗(intensity modulated radiation therapy,IMRT)复发性晚期卵巢癌的疗效。方法选取河南科技大学第一附属医院2015-01-05-2015-12-10收治的80例复发性晚期卵巢癌患者为研究对象,按照年龄、病理类型和临床分期组间匹配的原则分为两组,各40例。对照组采用铂类为主化疗方案治疗,观察组采用铂类为主化疗方案联合IMRT治疗,比较两组患者临床疗效、生活质量、随访生存率和毒副作用。结果观察组总控制率为95.00%,高于对照组的80.00%,χ^2=4.114,P=0.043;治疗后,观察组KPS评分为(82.47±6.22)分,高于对照组的(62.89±5.11)分,t=8.852,P<0.001;观察组随访1年生存率为75.00%,高于对照组的52.50%,χ^2=4.381,P=0.036;观察组随访3年生存率为57.50%,高于对照组的35.00%,χ^2=4.073,P=0.044;观察组肝功能损伤率为10.00%,与对照组15.00%比较,差异无统计学意义,χ^2=0.457,P=0.499;观察组骨髓抑制率为55.00%,与对照组47.50%比较,差异无统计学意义,χ^2=0.450,P=0.502;观察组脱发率为40.00%,与对照组37.50%比较,差异无统计学意义,χ^2=0.053,P=0.819;观察组消化道反应率为40.00%,与对照组35.00%比较,差异无统计学意义,χ^2=0.213,P=0.644。结论以铂类为主化疗方案联合IMRT治疗复发性晚期卵巢癌效果确切,可提升患者生存率及生活质量,且耐受性较好。OBJECTIVE Ovarian cancer is an important malignant tumor disease that causes death in women.Most patients are in advanced stage and have lost the opportunity for surgical treatment.Therefore,it is important to seek an effective treatment method to improve the quality of life of patients.This study aims to investigate the efficacy of platinum-based chemotherapy combined with intensity modulated radiation therapy(IMRT)in treatment of recurrent advanced ovarian cancer.METHODS A total of 80 patients with recurrent advanced ovarian cancer who admitted in First Affiliated Hospital of Henan University of Science and Technology from January 5 to December 10,2015 were selected as research objects.All selected cases were divided into two groups according to age,pathological pattern and clinical staging,with 40 cases in each group.The control group was given platinum-based chemotherapy,and the observation group was treated with platinum-based chemotherapy combined with IMRT.Clinical efficacy,quality of life,follow-up survival rate,toxicside effect were compared between two groups.RESULTS After treatment,the total control rate of observation group(95.00%)was higher than that of control group(80.00%),χ^2=4.114,P=0.043.After treatment,the KPS score of observation group(82.47±6.22)was higher than that of control group(62.89±5.11),t=8.852,P<0.001.The oneyear survival rate of observation group(75.00%)was higher than that of control group(52.50%),χ^2=4.381,P=0.036.The three-year survival rate observation group(57.50%)was higher than that of control group(35.00%),χ^2=4.073,P=0.044.The rate of liver function injury in the observation group was 10.00%,compared with 15.00%in the control group,the difference was not statistically significant,χ^2=0.457,P=0.499.The bone marrow inhibition rate in the observation group was 55.00%,and the difference was not statistically significant compared with 47.50%in the control group,χ^2=0.450,P=0.502.The hair loss rate in the observation group was 40.00%,and the difference was not statisticall

关 键 词：复发性晚期卵巢癌 调强放射治疗 铂类药物 生活质量 

分 类 号：R737.31[医药卫生—肿瘤]