超声引导下聚桂醇注射硬化治疗甲状腺囊肿的临床疗效观察  

Clinical effect of ultrasound-guided lauryl alcohol injection in the treatment of thyroid cyst

作　　者：费晓伟 戴元颖[1] 郭碧萍 Fei Xiaowei;Dai Yuanying;Guo Biping(Department of Ultrasound,the First People's Hospital of Huzhou,Huzhou,Zhejiang 313000,China)

机构地区：[1]湖州市第一人民医院超声科,浙江省313000

出　　处：《中国基层医药》2020年第19期2370-2374,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的:观察超声引导下聚桂醇硬化治疗对甲状腺囊肿的治疗效果及安全性。方法:选取2017年2月至2019年2月于湖州市第一人民医院就诊并接受治疗的甲状腺囊肿患者148例为研究对象,按照随机数字表法将所有研究对象分为研究组和对照组,每组74例患者,研究组患者行超声引导下聚桂醇注射硬化治疗,对照组患者行超声引导下的无水乙醇注射硬化治疗,比较患者治疗前与治疗6个月后血清游离三碘甲状腺原氨酸(FT 3)、游离四碘甲状腺原氨酸(FT 4)和促甲状腺素(TSH)水平变化,评价甲状腺囊肿疗效,观察治疗后不良反应情况。结果:两组患者组内及组间治疗前后血清TSH、FT 3和FT 4水平差异均无统计学意义(t=-0.514~0.624,P=0.513~0.852);研究组患者治疗后甲状腺囊肿总体治疗有效率(94.59%)显著高于对照组(82.43%)(χ2=5.382,P=0.020);研究组患者治疗后不良反应总发生率(12.16%)显著低于对照组(31.08%)(χ2=7.815,P=0.005)。结论:超声引导下聚桂醇及无水乙醇注射硬化治疗均不影响甲状腺囊肿患者甲状腺功能,而超声引导下聚桂醇硬化治疗有利于提高甲状腺囊肿疗效,且安全性更高。Objective:To observe the clinical effect and safety of lauryl alcohol injection under the guidance of ultrasound in the treatment of thyroid cyst.Methods:From February 2017 to February 2019,148 patients with thyroid cyst who had been treated in the First People's Hospital of Huzhou were divided into study group and control group according to the random number table method,with 74 patients in each group.The patients in the study group were treated with ultrasound-guided percutaneous injection of lauryl alcohol,while the patients in the control group were treated with ultrasound-guided percutaneous injection of anhydrous ethanol.The changes of serum free triiodothyronine(FT 3),free tetraiodothyronine(FT 4)and thyroid-stimulating hormone(TSH)were compared before treatment and after treatment for 6 months.The curative effect was evaluated and the adverse reactions were observed after treatment.Results:There were no statistically significant differences in the serum TSH,FT 3 and FT 4 between the two groups before and after treatment(t=-0.514~0.624,P=0.513~0.852).The overall effective rate in the study group(94.59%)was significantly higher than that in the control group(82.43%)(χ2=5.382,P=0.020).The overall incidence of adverse reactions in the study group(12.16%)was significantly lower than that in the control group(31.08%)(χ2=7.815,P=0.005).Conclusion:Ultrasound-guided injection of lauryl alcohol and anhydrous ethanol did not affect the thyroid function of patients with thyroid cysts,while ultrasound-guided injection of lauryl alcohol is conducive to improve the efficacy of thyroid cysts,and the safety is higher,which is worthy of clinical application.

关 键 词：甲状腺肿 结节性 超声检查 注射 病灶内 硬化疗法 聚桂醇 无水乙醇 

分 类 号：R736.1[医药卫生—肿瘤]