核糖体肽生物合成中的典型翻译后修饰研究  

Classic Post-translational Modification in Ribosomally Synthesized and Post-translationally Modified Peptides Biosynthesis

作　　者：汪金秀 张琪[2] 丁伟 陈拓 WANG Jin-xiu;ZHANG Qi;DING Wei;CHEN Tuo(Northwest Institute of Eco-Environmental and Resources,Chinese Academy of Sciences,Lanzhou 73000;Fudan University,Shanghai 200433;University of Chinese Academy of Sciences,Beijing 100049;School of Life Sciences and Biotechnology,Shanghai Jiaotong University,Shanghai 200030)

机构地区：[1]中国科学院西北生态环境资源研究院,兰州730000 [2]复旦大学化学系,上海200433 [3]中国科学院大学,北京100049 [4]上海交通大学生命科学技术学院,上海200030

出　　处：《生物技术通报》2020年第10期215-225,共11页Biotechnology Bulletin

基　　金：国家自然科学青年科学基金项目(31600398);甘肃杰出青年基金项目(17JR5RA308)。

摘　　要：核糖体肽类天然产物(RiPPs)是由核糖体合成,经由翻译后修饰得到的一大类天然产物,具有广泛的结构和生物活性多样性。综述了核糖体肽的类别及种类众多的翻译后修饰机理,探讨了翻译后修饰对结构多样性的意义,并对生物信息学背景下利用基因组挖掘技术来开发更多RiPPs做了展望。Ribosomally synthesized and post-translationally modified peptides(RiPPs)are a large class of natural products synthesized by ribosome via post-translational modification which feature a wide range of structural and biological diversity.We reviewed the various classes of RiPPs and their post-translationally modification mechanisms,discussed the significance of post-translational modifications,and prospected the development of RiPPs using genome mining under bioinformatics.

关 键 词：核糖体肽 后修饰 生物合成途径 基因组挖掘 

分 类 号：Q753[生物学—分子生物学]