阿龙山病毒感染者肝功能和凝血功能临床特点分析  

Clinical features of liver function and coagulation function in patients with Alongshan virus infection

作　　者：张力 吕小龙[4] 徐洪芹 王泽东 王伟 王波 魏伟 牛俊奇 韩淑祯[4] 刘全[1,6] ZHANG Li;LYU Xiaolong;XU Hongqin;WANG Zedong;WANG Wei;WANG Bo;WEI Wei;NIU Junqi;HAN Shuzhen;LIU Quan(Department of Emerging Infectious Diseases,The First Hospital of Jilin University,Changchun 130021,China;Department of Hepatology,The First Hospital of Jilin University,Changchun 130021,China;Institute of AIDS and Viruses,The First Hospital of Jilin University,Changchun 130021,China;Department of Neurology,Inner Mongolia General Forestry Hospital,Yakeshi 022150,Inner Mongolia Autonomous Region,China;Department of Neurosurgery,Inner Mongolia General Forestry Hospital,Yakeshi 022150,Inner Mongolia Autonomous Region,China;Jilin University,Changchun 130061,China)

机构地区：[1]吉林大学第一医院新发传染病研究室,长春130061 [2]吉林大学第一医院肝胆胰内科,长春130061 [3]吉林大学第一医院艾滋病与病毒研究所,长春130061 [4]内蒙古林业总医院神经内科,内蒙古牙克石022150 [5]内蒙古林业总医院神经外科,内蒙古牙克石022150 [6]吉林大学,长春130061

出　　处：《临床肝胆病杂志》2020年第10期2258-2260,共3页Journal of Clinical Hepatology

基　　金：国家重点研发项目(2017YFD0501700);国家自然科学基金青年科学基金项目(82002165)。

摘　　要：目的分析阿龙山病毒(ALSV)感染者肝功能和凝血功能临床特点。方法收集2018年5月-2019年9月内蒙古林业总医院收治的27例ALSV感染者的临床资料,其中男18例,女9例。提取、建立相关病例报告数据库,用描述性流行病学方法分析其肝功能和凝血指标的临床特征,分析ALSV感染引起的肝功能损伤特点。结果27例患者中ALT、AST、ALP、GGT、CHE、TBA的异常率分别是25.9%、33.3%、25.9%、40.7%、8%、8%,其水平超过2倍正常值上限的分别为ALT 4例(14.8%)、AST 3例(11.1%)、ALP 1例(3.7%)和GGT 5例(18.5%),27例患者中有胆红素检查结果的患者25例(男17例,女8例),其中1例TBil水平下降,为3.30μmol/L,3例TBil水平升高,分别为23.7、26.2和32.0μmol/L。凝血指标的国际标准化比值、部分凝血活酶、纤维蛋白原异常率分别为3.7%、11.1%和22.2%。结论ALSV感染者中有一定程度的肝损伤,但一般症状较轻。Objective To investigate the clinical features of liver function and coagulation function in patients with Alongshan virus(ALSV)infection.Methods Clinical data were collected from 27 patients with ALSV infection who were admitted to Inner Mongolia General Forestry Hospital from May 2018 to September 2019,among whom there were 18 male patients and 9 female patients.Related data were extracted,and a database of relevant case reports was established.The descriptive epidemiological method was used to analyze the clinical features of liver function and coagulation markers,and the features of liver injury caused by ALSV infection were analyzed.Results For the 27 patients,the abnormal rates of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),gamma-glutamyl transpeptidase(GGT),cholinesterase,and total bile acid were 25.9%,33.3%,25.9%,40.7%,8%,and 8%,respectively;among the 27 patients,4(14.8%)had an ALT level of>2×upper limit of normal(ULN),3(11.1%)had an AST level of>2×ULN,1(3.7%)had an ALP level of>2×ULN,and 5(18.5%)had a GGT level of>2×ULN.Among the 27 patients,25(17 male patients and 8 female patients)had the results of bilirubin test,among whom 1 had a reduction in total bilirubin(TBil)(3.30μmol/L)and 3 had an increase in TBil(23.7μmol/L,26.2μmol/L,and 32μmol/L,respectively).The abnormal rates of the coagulation markers international normalized ratio,activated partial thromboplastin time,and fibrinogen were 3.7%,11.1%,and 22.2%,respectively.Conclusion There is a certain degree of liver injury in patients with ALSV infection,generally with mild symptoms.

关 键 词：阿龙山病毒 肝疾病 血液凝固因子 

分 类 号：R575[医药卫生—消化系统]