线粒体功能异常在非酒精性脂肪性肝病发生中的机制  

Mechanism of mitochondrial dysfunction in the development of nonalcoholic fatty liver disease

作　　者：徐梓馨 罗声政[1] 徐铭益[1] XU Zixin;LUO Shengzheng;XU Mingyi(Department of Gastroenterology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学附属第一人民医院消化内科,上海200080

出　　处：《临床肝胆病杂志》2020年第10期2353-2355,共3页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81570547,81770597);国家科技部“十三五”重大专项(2017ZX10203202003005)。

摘　　要：非酒精性脂肪性肝病(NAFLD)是一个复杂的、多因素影响的一些系列的疾病。线粒体功能障碍常发生在NAFLD中,并导致肝炎、肝纤维化的进展。阐述了线粒体氧化应激、呼吸作用、能量代谢、质量控制以及线粒体DNA在NAFLD中发挥的重要作用,并总结了NAFLD的线粒体靶向治疗现状,希望为NAFLD的研究及临床治疗提供新的方向。Nonalcoholic fatty liver disease(NAFLD)includes a series of diseases affected by various complex factors.Mitochondrial dysfunction often occurs in NAFLD and may lead to the progression of hepatitis and liver fibrosis.This article reviews the important role of mitochondrial oxidative stress,respiration,energy metabolism,quality control,and mitochondrial DNA in NAFLD and summarizes the current status of mitochondria-targeted therapy for NAFLD,hoping to provide a new direction for the research and clinical treatment of NAFLD.

关 键 词：非酒精性脂肪性肝病 线粒体 分子靶向治疗 

分 类 号：R575.5[医药卫生—消化系统]