基质金属蛋白酶2/9在慢性肝脏疾病发生发展中的作用  

Role of matrix metalloproteinases-2 and matrix metalloproteinases-9 in the development and progression of chronic liver diseases

作　　者：杨尚青 杨东亮[1] 刘嘉[1] YANG Shangqing;YANG Dongliang;LIU Jia(Department of Infectious Diseases,Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院感染性疾病科,武汉430022

出　　处：《临床肝胆病杂志》2020年第10期2364-2369,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81861138044,91642118,91742114);国家科技重大专项资助项目(2017ZX10202202,2017ZX10202201,2017ZX10202203-007-006);华中科技大学同济医学院重大疾病交叉创新团队资助项目。

摘　　要：细胞外基质的降解和重塑是多种慢性肝脏疾病进展过程中的重要病理生理现象。近年来,随着对基质金属蛋白酶(MMP)研究的不断拓展,发现其不仅可影响细胞外基质的降解和重塑过程,还可通过多种机制参与炎症及免疫应答的发生和调控,进而参与肝脏疾病的进程。简述了MMP家族成员MMP-2/MMP-9的基本特性、表达活性调控机制及其在多种慢性肝脏疾病发生发展中的作用,旨在为探索慢性肝脏疾病新的治疗策略提供依据。The degradation and remodelling of extracellular matrix are important pathophysiological phenomena during the progression of various chronic liver diseases.With the expanded research on matrix metalloproteinases(MMPs)in recent years,it has been found that MMPs can affect the degradation and remodelling of extracellular matrix,participate in the regulation of inflammation and immune responses through various mechanisms,and thus participate in the progression of liver diseases.This article reviews the basic characteristics of matrix metalloproteinase-2 and matrix metalloproteinase-9,their regulatory mechanisms,and their role in the development and progression of chronic liver diseases,so as to provide a basis for exploring new therapeutic strategies for chronic liver diseases.

关 键 词：肝疾病 基质金属蛋白酶2 基质金属蛋白酶9 免疫 

分 类 号：R575[医药卫生—消化系统]