重组小鼠白介素-33对小鼠实体瘤的抑制作用  

Antitumor effect of recombinant mouse interleukin-33 in mice

作　　者：蒋丽娅 罗平 邓少荣 叶浩[1] 俞雁[2] 韩伟[1] JIANG Liya;LUO Ping;DENG Shaorong;YE Hao;YU Yan;HAN Wei(Laboratory of Regeneromics,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240;Shanghai Municipality Key Laboratory of Veterinary Biotechnology,School of Agriculture and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]上海交通大学药学院,再生组学实验室,上海200240 [2]上海交通大学农业与生物学院,上海市兽医生物技术重点实验室,上海200240

出　　处：《中国药科大学学报》2020年第5期584-590,共7页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81673446/H3105)。

摘　　要：为探究重组小鼠白介素-33(mIL-33)对不同类型肿瘤的作用,采用外源性注射mIL-33的方法对荷不同实体瘤的小鼠模型进行药效学研究。本研究发现mIL-33能够显著抑制肝癌、肺癌、胃癌、前列腺癌和结肠癌的生长,但对不同肿瘤抑制作用并不完全一致。较低剂量的mIL-33(10μg/kg)能显著抑制肝癌、肺癌和胃癌皮下荷瘤小鼠的肿瘤生长;而在前列腺癌和结肠癌皮下荷瘤小鼠模型中,需要较高剂量的mIL-33(90μg/kg)才能发挥相应的抗肿瘤作用。此外,mIL-33对结肠癌皮下荷瘤的生长抑制作用还与给药时长及肿瘤进展时期相关。研究结果表明,mIL-33能够显著抑制小鼠多种肿瘤的生长,提示IL-33可能是治疗肿瘤的有效靶点。To explore the effect of IL-33 on various tumor types,exogenous injection of recombinant mouse IL-33 protein(mIL-33)was used to study the efficacy of different subcutaneous tumor-bearing mouse models.In this study,mIL-33 has been found to significantly inhibit the growth of liver,lung,gastric,prostate,and colon cancers.However,the inhibition of tumor growth by mIL-33 was not completely consistent in different types of tumor.A lower dose of mIL-33(10μg/kg)significantly inhibited tumor growth in subcutaneous tumor-bearing mice of liver,lung,and gastric cancers,while a higher dose of mIL-33(90μg/kg)was required to exert the corresponding antitumor effect in subcutaneous tumor-bearing mouse models with prostate and colon cancers.In addition,the growth inhibitory effect of mIL-33 on subcutaneous tumors of colon cancer was also correlated with the duration of administration and the stage of tumor progression.The results of this study indicate that mIL-33 significantly inhibits the growth of a variety of tumors,suggesting that IL-33 might be an effective target for tumor treatment.

关 键 词：重组小鼠白介素-33 抗肿瘤 肝癌 肺癌 前列腺癌 结肠癌 

分 类 号：R730.[医药卫生—肿瘤]