棕色脂肪的分泌功能  

Secretory Role of Brown Adipose Tissue

作　　者：徐跃洁 潘洁敏[1] XU Yuejie;PAN Jiemin(Shanghai Diabetes Institute,Department of Endocrinology and Metabolism,Affiliated Sixth People’s Hospital,Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病研究所,上海200233

出　　处：《中国医学科学院学报》2020年第5期681-685,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81670778)。

摘　　要：棕色脂肪通过解偶联蛋白1将化学能转化为热能,在底物氧化中具有高活性,其活化可引起机体能量消耗增加,血糖和血脂水平降低,促进内环境稳态平衡。以往将棕色脂肪的代谢作用归因于其解偶联呼吸和产热功能,最近研究表明棕色脂肪具有分泌功能,分泌因子在局部或全身发挥作用来影响能量代谢。因此,棕色脂肪分泌因子的识别有助于全面了解棕色脂肪组织在代谢中的作用,并进一步扩展代谢性疾病的潜在治疗策略。Brown adipose tissue(BAT)can convert chemical energy into thermal energy by uncoupling protein 1.It has high activity in substrate oxidation,and its activation can increase the whole energy consumption,lower the blood glucose and lipid levels,and promote the body homeostasis.Previous literature has attributed the metabolism role of BAT to its uncoupled respiratory and thermogenic functions,whereas recent studies have shown that BAT has secretory function,and the secretory factors exert local or systemic effects on energy metabolism.Therefore,a better understanding of the roles of BAT-derived factors in metabolism may help to optimize the treatment of metabolic diseases.

关 键 词：棕色脂肪 分泌 脂肪因子 能量代谢 产热 

分 类 号：R363.1[医药卫生—病理学] R589[医药卫生—基础医学]