Rspos和消化系统肿瘤的关系  

Rspos and malignant tumors of digestive system

作　　者：王骞 王萌 谭林 屈伟明 周红兵[1] 陈维顺[1] WANG Qian;WANG Meng;TAN Lin;QUWeiming;ZHOU Hongbing;CHENWeishun(Department of Gastroenterology,Zhuzhou Hospital Affiliated to Xiangya School of Medicine,Central South University,Zhuzhou Hunan 412007;Comprehensive Ward,Zhuzhou Hospital Affiliated to Xiangya School of Medicine,Central South University,Zhuzhou Hunan 412007,China)

机构地区：[1]中南大学湘雅医学院附属株洲医院消化内科,湖南株洲412007 [2]中南大学湘雅医学院附属株洲医院综合病区,湖南株洲412007

出　　处：《中南大学学报（医学版）》2020年第9期1115-1119,共5页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(2018JJ3895,2019JJ60085)。

摘　　要：特异性顶部盘状底板反应蛋白(roof plate specific spondins,Rspos)是新近发现的Wnt信号通路的重要激活因子,包括Rspo1~4四种分泌蛋白质。Rspos主要通过调节经典Wnt/β-catenin信号通路来调控细胞的增殖与分化,其主要生理功能包括调节性别选择、肢体发育和器官形成与发育等。此外,Rspos还参与了部分恶性肿瘤的发病过程,且在不同类型肿瘤中的作用并不一致。Roof plate specific spondins(Rspos)are important activators of the Wnt signaling pathway discovered recently.Rspos include four secreted proteins:Rspo1,Rspo2,Rspo3,and Rspo4.They are mainly involved in the regulation of cell proliferation and differentiation via regulating the canonical Wnt/β-catenin signaling pathway.The physiological functions of Rspos include regulating sex selection,limb development,organ formation and development.Rspos are involved in the pathogenesis of some malignant tumors,and the roles of Rspos vary in different types of tumors.

关 键 词：特异性顶部盘状底板反应蛋白 WNT/Β-CATENIN信号通路 恶性肿瘤 

分 类 号：R735[医药卫生—肿瘤]