重复经颅磁刺激对轻中度阿尔茨海默病患者认知功能的影响  

Effects of r TMS on Cognitive Function in Patients With the Light to Moderate Alzheimer’s Disease

作　　者：高明 郝楷荣 叶装 陈明森 程文桃 黄炜静 陈元生 GAO Ming;HAO Kairong;YE Zhuang;CHEN Mingsen;CHENG Wentao;HUANG Weijing;CHEN Yuansheng(Department of Psychiatry,Fuzhou Neuro-Psychiatric Hospital,Fuzhou Fujian 350008,China)

机构地区：[1]福建省福州神经精神病防治院精神科,福建福州350008

出　　处：《中国卫生标准管理》2020年第19期44-47,共4页China Health Standard Management

基　　金：福州市科技计划项目(2018-S-104-3);福州市临床重点专科建设项目(201710271)。

摘　　要：目的研究重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对轻中度阿尔茨海默病(Alzheimer's disease,AD)患者认知功能的影响。方法将34例轻中度阿尔茨海默病患者分为两组,分别给予rTMS+多奈哌齐治疗(研究组)及多奈哌齐治疗(对照组),疗程共24周。阿尔茨海默病评定量表认知分量表(Alzheimer's disease assessment scale-cognitive,ADAS-Cog)和蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)作疗效评定。监测基线及治疗后3个月、6个月认知量表评分。结果两组基线资料差异无统计学意义(P>0.05)。治疗前后,两组患者组内及组间比较的认知量表总分差异均有统计学意义。治疗前后,两组内MoCA量表的延迟记忆、抽象项目分和ADAS-Cog量表的记忆、操作因子分差异有统计学意义(P<0.05)。两组间比较,6个月末MoCA量表延迟记忆项目分差异有统计学意义(P<0.05),3个月末ADAS-Cog量表单词回忆任务、单词辨认任务及24周末单词辨认任务项目分差异有统计学意义(P<0.05)。结论rTMS可改善轻中度AD患者认知缺陷,且以改善患者记忆功能为主,可考虑作为改善轻中度AD患者认知的辅助治疗手段。Objective To study the effects of rTMS on cognitive function in light to moderate Alzheimer’s.Methods 34 patients with light to moderate AD were randomly divided into two groups,the treatment of r TMS and donepezil(study group)and donepezil treatment(control group)were given for a total of 24 weeks.Assessment scale-cognitive(ADASCog)and Montreal cognitive assessment(MoCA)were given to evaluate the cognitive function.Before and 12 weeks,24 weeks after treatment,cognition function evaluation meters were performed.Results There were no statistically significant difference on basic data within the groups(P>0.05).After treatment,the differences in cognitive scale within and between the groups were statistically significant(P<0.05).recall project and abstract item series of MoCA scale、memory and operational factor score of ADAS-Cog scale were statistically significant in the two groups were statistically significant(P<0.05).Comparing the two groups,At the end of the third month,recall tasks、word recognition tasks were statistically significant.At the end of the six months,late recall of MoCA scale and word recognition tasks of ADAS-Cog scale were statistically different(P<0.05).Conclusion rTMS can improve cognitive impairment in patients with light to moderate AD and improve patient memory function,which can be considered as an complementary treatment to improve cognition in AD patients.

关 键 词：重复经颅磁刺激(rTMS) 阿尔茨海默病(AD) 阿尔茨海默病评定量表认知分量表(ADAS-Cog) 蒙特利尔认知评估量表(MoCA) 认知功能 记忆 

分 类 号：R743[医药卫生—神经病学与精神病学]