小金片联合米非司酮治疗腹痛症状子宫肌瘤疗效  

Clinical efficacy of Xiaojin tablets combined with mifepristone for treating women with abdominal pain because of uterine fibroids

作　　者：蒲秀敏 黄勇[1] 严俊[1] 谢晓琴[1] 王云 PU Xiumin;HUANG Yong;YAN Jun;XIE Xiaoqin;WANG Yun(The Third People's Hospital of Chengdu City,Sichuan Province,610000;The First Hospital of Xi'an)

机构地区：[1]四川省成都市第三人民医院,610000 [2]陕西省西安市第一医院

出　　处：《中国计划生育学杂志》2020年第10期1601-1605,共5页Chinese Journal of Family Planning

基　　金：四川省卫生厅(17PJ613)。

摘　　要：目的:观察中成药小金片联合米非司酮治疗腹痛症状子宫肌瘤患者的临床疗效。方法:选取2017年1月-2019年1月本院有腹痛症状子宫肌瘤患者104例,采用随机数字表法分为观察组和对照组各52例,对照组口服米非司酮治疗,观察组口服米非司酮联合小金片治疗。比较两组治疗3个月后临床疗效,治疗前、治疗3个月后肌瘤体积,主要症状积分,血清卵泡生长激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕激素(P)、雌激素受体(ER)、孕激素受体(PR)、血管内皮生长因子(VEGF)水平及6个月时复发情况。结果:治疗3个月后,观察组治疗总有效率(94.2%)高于对照组(78.9%),肌瘤体积两组均较治疗前缩小且观察组(7.32±1.57cm^3)小于对照组(12.36±2.03cm^3),两组下腹部疼痛、乳房胀痛、经期延长、月经过多、倦怠无力等主要症状积分均较治疗前降低且观察组低于对照组,两组血清FSH、LH、E2、P、ER、PR、VEGF均较治疗前降低且观察组低于对照组,停药后6个月内复发率观察组(7.7%)低于对照组(40.4%)(P均<0.05);用药期间不良反应发生率(5.8%、7.7%)两组无差异(P>0.05)。结论:小金片联合米非司酮治疗子宫肌瘤,可更好改善腹痛等症状及性激素水平,降低复发风险,且安全有效。Objective: To observe the clinical efficacy of Xiaojin tablets combined with mifepristone for treating women with abdominal pain because of uterine fibroids. Methods: 104 women with abdominal pain because of uterine fibroids were selected and divided into study group and control group(52 cases in each group) according to the random number table method from January 2017 to January 2019. The women in the control group were treated with mifepristone, and the women in study group were treated with mifepristone combined with Xiaojin tablets. The clinical efficacy, the fibroid volume, main symptom scores, and the levels of serum biochemical indicators, such as follicular growth hormone(FSH), luteinizing hormone(LH), estradiol(E2), progesterone(P), estrogen receptor(ER), progesterone receptor(PR), and vascular endothelial growth factor(VEGF) after 3 months of treatment, and the recurrence rate after 6 months of treatment were compared between the two groups. Results: After 3 months of treatment, the total effective rate of women in study group was significant higher than that of women in control group, the fibroid volume of women in the two groups after treatment had reduced significantly, and the fibroid volume of women in the study group was 7.32±1.57 cm3, which was significant less than that(12.36±2.03 cm3) of women in control group(P<0.05). After treatment, the scores of main symptoms of lower abdominal pain, and the rates of breast tenderness, prolonged menstruation, menometrorrhagia, and fatigue of women in the two group had decreased significantly, and those of women in the study group were significant lower than those of women in control group(P<0.05). After treatment,the levels of serum FSH, LH, E2, P, ER, PR and VEGF of women in the two group had decreased significantly, and those of women in the study group were significant lower than those of women in control group(P<0.05). Within 6 months after discontinuation drugs used, the recurrence rate of women in study group was 7.7%, which was significant lower th

关 键 词：子宫肌瘤 腹痛 米非司酮 小金片 临床疗效 性激素 复发 

分 类 号：R737.33[医药卫生—肿瘤]