慢性荨麻疹合并Hp感染患者血清总IgE ECP和HRF浓度的相关性分析  

Correlation Analysis of Serum Total IgE,ECP and HRF Concentrations in Patients with Chronic Urticaria Complicated with Hp Infection

作　　者：孔德华 黄玮 赵桂苹 程文婷 KONG Dehua;HUANG Wei;ZHAO Guiping(Gaochun People's Hospital,Jiangsu Nanjing 211300,China)

机构地区：[1]江苏省南京市高淳人民医院检验科,江苏南京211300

出　　处：《河北医学》2020年第10期1652-1655,共4页Hebei Medicine

基　　金：江苏省2014年度卫生厅面上科研课题,(编号:H2014507)。

摘　　要：目的:分析慢性荨麻疹合并Hp感染患者血清总免疫球蛋白E(IgE)、嗜酸性粒细胞阳离子蛋白(ECP)和组胺释放因子(HRF)浓度的相关性分析。方法:76例荨麻疹患者依据病情程度分为轻度组(13例)、中度组(38例)和重度组(25例),依据Hp感染情况分为Hp阳性组(48例)和Hp阴性组(28例),同期收集健康志愿者68例作为对照组,比较各组血情总IgE、ECP和HRF水平,并进行相关性分析。结果:荨麻疹组血清总IgE、ECP和HRF水平高于对照组(P<0.05)。荨麻疹患者重度组血清总IgE、ECP和HRF水平高于中度组及轻度组,中度组血清总IgE、ECP和HRF水平高于轻度组(P<0.05)。Hp阳性荨麻疹组血清总IgE、ECP、HRF和Hp水平高于Hp阴性荨麻疹组(P<0.05)。经Pearson相关性分析,血清总IgE、ECP、HRF水平和Hp均呈正相关(P值均<0.05)。结论:荨麻疹感染合并Hp感染能够促进血清总IgE、ECP及HRF的表达,增加病情程度。Objective:To analyze the correlation between serum total immunoglobulin E(IgE),eosinophil cationic protein(ECP)and histamine release factor(HRF)and helicobacter pylori(Hp)infection in urticaria.Methods:76 patients with urticaria were divided into mild group(13 cases),moderate group(38 cases)and severe group(25 cases)according to the severity of the disease.They were divided into Hp positive group(48 cases)and Hp negative group(28 cases)according to the Hp infection,at the same time,68 healthy volunteers were collected as control group.The levels of total IgE,ECP and HRF in blood of each group were compared and correlation analysis was carried out.Results:The levels of serum total IgE,ECP and HRF in urticaria group were higher than those in control group(P<0.05).The levels of serum total IgE,ECP and HRF in severe urticaria group were higher than those in moderate group and mild group,and the serum total IgE,ECP and HRF levels in moderate group were higher than those in mild group(P<0.05).The levels of serum IgE,ECP,HRF and HP in HP positive urticaria group were higher than those in HP negative urticaria group(P<0.05).Pearson correlation analysis showed that serum total IgE,ECP,HRF levels were positively correlated with HP(P<0.05).Conclusion:Urticaria infection combined with HP infection can promote the expression of serum total IgE,ECP and HRF,and increase the severity of the disease.

关 键 词：荨麻疹 幽门螺杆菌感染 总免疫球蛋白E 嗜酸性粒细胞阳离子蛋白 组胺释放因子 

分 类 号：R573[医药卫生—消化系统] R758.24[医药卫生—内科学]