精确放疗联合吉非替尼治疗老年EGFR突变阳性局部晚期非小细胞肺癌的疗效  

Efficacy of precision radiotherapy combined with gefitinib in the treatment of elderly patients with EGFR mutation-positive locally advanced non-small cell lung cancer

作　　者：徐家亮 徐春华 姜美慧 吴宏久 XU Jia-liang;XU Chun-hua;JIANG Mei-hui(Department of Radiotherapy,Wafangdian Central Hospital,Wafangdian 116300,China)

机构地区：[1]瓦房店市中心医院放疗科,116300 [2]瓦房店市中心医院肿瘤内二科,116300

出　　处：《中国现代药物应用》2020年第20期117-119,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析在治疗老年表皮生长因子受体(EGFR)突变阳性局部晚期非小细胞肺癌(NSCLC)时应用精确放疗联合吉非替尼的疗效。方法 80例老年EGFR突变阳性局部晚期NSCLC患者,根据病例单双号分为治疗A组与治疗B组,各40例。治疗A组进行单纯放疗,治疗B组进行精确放疗联合吉非替尼治疗。比较两组治疗效果及不良反应发生情况。结果治疗B组的病情控制率为92.50%,高于治疗A组的72.50%,差异有统计学意义(P<0.05)。治疗A组不良反应发生率为25.00%,与治疗B组的30.00%比较,差异无统计学意义(P>0.05)。结论在治疗老年EGFR突变阳性局部晚期NSCLC时应用精确放疗联合吉非替尼可有效提高患者的治疗效果,且并不会增加其不良反应发生率,具有积极影响作用。Objective To analyze the efficacy of precision radiotherapy combined with gefitinib in the treatment of elderly patients with epidermal growth factor receptor(EGFR)mutation-positive locally advanced non-small cell lung cancer(NSCLC).Methods A total of 80 elderly patients with EGFR mutation-positive locally advanced non-small cell lung cancer were divided into treatment group A and treatment group B according to case number,with 40 cases in each group.Treatment group A received radiotherapy alone,and treatment group B received precise radiotherapy combined with gefitinib.The therapeutic effect and occurrence of adverse reactions were compared between the two groups.Results The disease control rate of treatment group B was 92.50%,which was higher than 72.50%of treatment group A,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of treatment group A was 25.00%,which had no statistically significant difference compared with 30.00%of treatment group B,and the difference was statistically significant(P>0.05).Conclusion In the treatment of elderly EGFR mutation-positive locally advanced NSCLC,the application of precision radiotherapy combined with gefitinib has a positive effect,and can effectively improve the treatment effect of patients without increasing the incidence of adverse reactions.

关 键 词：表皮生长因子受体 非小细胞肺癌 精确放疗 吉非替尼 

分 类 号：R734.2[医药卫生—肿瘤]