The theory of helix-based RNA folding kinetics and its application  

作　　者：Sha Gong Taigang Liu Yanli Wang Wenbing Zhang 龚沙;刘太刚;王晏莉;张文炳(Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization,Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains,Huanggang Normal University,Huanggang 438000,China;Department of Physics,Wuhan University,Wuhan 430072,China)

机构地区：[1]Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization,Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains,Huanggang Normal University,Huanggang 438000,China [2]Department of Physics,Wuhan University,Wuhan 430072,China

出　　处：《Chinese Physics B》2020年第10期9-16,共8页中国物理B（英文版）

基　　金：Project supported by the Science Fund from the Key Laboratory of Hubei Province, China (Grant No. 201932003);the National Natural Science Foundation of China (Grant Nos. 1157324 and 31600592).

摘　　要：RNAs carry out diverse biological functions, partly because different conformations of the same RNA sequence can play different roles in cellular activities. To fully understand the biological functions of RNAs requires a conceptual framework to investigate the folding kinetics of RNA molecules, instead of native structures alone. Over the past several decades, many experimental and theoretical methods have been developed to address RNA folding. The helix-based RNA folding theory is the one which uses helices as building blocks, to calculate folding kinetics of secondary structures with pseudoknots of long RNA in two different folding scenarios. Here, we will briefly review the helix-based RNA folding theory and its application in exploring regulation mechanisms of several riboswitches and self-cleavage activities of the hepatitis delta virus (HDV) ribozyme.

关 键 词：RNA folding kinetics RNA structure RIBOSWITCH HDV ribozyme 

分 类 号：Q522[生物学—生物化学]