RIBOSWITCH

作品数:12被引量:16H指数:2
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相关领域:生物学更多>>
相关作者:单战杨鹏郭江峰张凯来鲁华更多>>
相关机构:浙江理工大学北京大学更多>>
相关期刊:《Science China Chemistry》《微生物学通报》《Advances in Microbiology》《mLife》更多>>
相关基金:国家自然科学基金浙江省重点科技创新团队项目国家重点基础研究发展计划更多>>
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A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis
《Synthetic and Systems Biotechnology》2024年第3期513-521,共9页Xia Yang Huiying Wang Dongqin Ding Huan Fang Huina Dong Dawei Zhang 
supported by the National Key R&D Program of China[Grant number 2021YFC2100700];the National Natural Science Foundation of China[Grant numbers 22178372,32300069];TIB-VIB Joint Center of Synthetic Biology[Grant number TSBICIP-IJCP-002];the National Science Fund for Distinguished Young Scholars[Grant number 22325807];the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project[Grant numbers TSBICIP-KJGG-011,TSBICIP-CXRC-055];the Yellow River Delta Industry Leading Talents[Grant number DYRC20190212].
Genetically encoded circuits have been successfully utilized to assess and characterize target variants with desirable traits from large mutant libraries.Adenosylcobalamin is an essential coenzyme that is required in ...
关键词:Adenosylcobalamin Genetically encoded biosensor RIBOSWITCH Transcriptional repressor High-throughput screening 
A DnaA-dependent riboswitch for transcription attenuation of the his operon
《mLife》2023年第2期126-140,共15页Yuan Yao Hongwei Sun Wurihan Gegeheng Gezi Kirsten Skarstad Lifei Fan Morigen 
supported by grants from the National Natural Science Foundation of China(Grant no.32260233 to Morigen);the Science and Technology Foundation of Inner Mongolia(Inner Mongolia Key Laboratory for Molecular Regulation of the Cell,Grant no.2021PT0002).
Transcription attenuation in response to the availability of a specific amino acid is believed to be controlled by alternative configurations of RNA secondary structures that lead to the arrest of translation or the r...
关键词:DnaA-dependent Escherichia coli his operon RIBOSWITCH transcription attenuation 
Parallel screening and cheminformatics modeling of flavonoid activated aptasensors
《Synthetic and Systems Biotechnology》2022年第4期1148-1158,共11页Yu Xiu Ni Zhang Pranesha Prabhakaran Sungho Jang Qipeng Yuan Curt MBreneman Gyoo Yeol Jung Wanwipa Vongsangnak Mattheos A.G.Koffas 
This work was supported by the Global Research Laboratory Program(NRF 2016K1A1A2912829)through the National Research Foundation of Korea(NRF);This work was also supported by the National Natural Science Foundation of China(grant number 21636001);Research Program of Beijing Municipal Education Commission(grant number KM201911417012);This work was also financially supported by the Office of the Ministry of Higher Education,Science,Research and Innovation;the Thailand Science Research and Innovation through the Kasetsart University Reinventing University Program 2021 and Department of Zoology,Faculty of Science,Kasetsart University;P.P.would like to acknowledge the supports provided by the International Affairs under the scholarship program of ASEAN+6 and Interdisciplinary Graduate Program in Bioscience in Kasetsart University.
A parallel screening of 27 different flavonoids and chalcones was conducted using 6 artificial naringenin-activated riboswitches(M1,M2,M3,O,L and H).A quantitative structure-property relationship approach was applied ...
关键词:RIBOSWITCH RNA device FLAVONOIDS Structure-property relationships Physicochemical properties 
The theory of helix-based RNA folding kinetics and its application
《Chinese Physics B》2020年第10期9-16,共8页Sha Gong Taigang Liu Yanli Wang Wenbing Zhang 
Project supported by the Science Fund from the Key Laboratory of Hubei Province, China (Grant No. 201932003);the National Natural Science Foundation of China (Grant Nos. 1157324 and 31600592).
RNAs carry out diverse biological functions, partly because different conformations of the same RNA sequence can play different roles in cellular activities. To fully understand the biological functions of RNAs requir...
关键词:RNA folding kinetics RNA structure RIBOSWITCH HDV ribozyme 
Folding Behaviors of Purine Riboswitch Aptamers
《Wuhan University Journal of Natural Sciences》2018年第1期43-50,共8页GONG Sha WANG Yanli WANG Zhen SUN Yuying ZHANG Wenbing 
Supported by the National Natural Science Foundation of China(31600592);Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization,Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains(2017BX08)
Most riboswitches are characterized by two components, an aptamer domain that folds into a unique ligand binding pocket to interact with the ligand, and an expression platform that converts folding changes in the apta...
关键词:purine riboswitch gene regulation APTAMER co-transcriptional folding 
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening被引量:3
《Frontiers of Chemical Science and Engineering》2017年第1期15-26,共12页Qingzhuo Wang Shuang-Yan Tang Sheng Yang 
Overproduction of small-molecule chemicals using engineered microbial cells has greatly reduced the production cost and promoted environmental protection. Notably, the rapid and sensitive evaluation of the in vivo con...
关键词:BIOSENSOR small molecule product transcrip-tion factor RIBOSWITCH high-throughput screening 
Construction of a genetic conditional learning system in Escherichia coli
《Science China(Information Sciences)》2015年第11期172-177,共6页CHEN Mei XU Jin 
supported by National Basic Research Program of China(973 Program)(Grant Nos.2013CB3296-01,2013CB329602);National Natural Science Foundation of China(Grant Nos.61127005,60910002,61379059,61472333,61402382,30970960);"Top University,Top Discipline"Funds for Minzu University of China(Grant No.10301-0150200518)
Currently, there are a lot of man-made biomolecular computing systems. However, it is rare to see man-made biomolecular intelligence system. Learning ability is one of the basic abilities of intelligence. Many organis...
关键词:biomolecular computing artificial intelligence conditional learning MEMORY RIBOSWITCH DNA recombinase 
Induced Transcriptional Expression of <i>Bacillus subtilis</i>Amino Acid Permease <i>yvbW</i>in Response to Leucine Limitation
《Advances in Microbiology》2014年第8期484-492,共9页Sean M. Rollins 
T box sequences have been identified upstream of a large number of uncharacterized genes such as transporters in bacterial genomes. Expression of each T box family gene is induced by limitation for a specific amino ac...
关键词:T Box Antitermination RIBOSWITCH Amino Acid PERMEASE YvbW 
细菌中黄素单核苷酸核糖开关研究进展被引量:2
《微生物学通报》2014年第8期1655-1660,共6页单战 张凯 郭江峰 
国家自然科学基金项目(No.11105121);浙江省创新团队项目(No.2012R10033-07)
核糖开关(Riboswitch)具有RNA结构,是位于mRNA 5′非编码区的RNA传感器。在无任何蛋白质因子参与下,可特异性地直接结合代谢产物,使自身构象发生相应变化,启动或阻断mRNA的转录、翻译、拼接等过程来调控基因的表达。某些Riboswitch可应...
关键词:核糖开关 FMN RIBOSWITCH SRNA 基因调控 药物设计 
基于Riboswitch的细胞与门构建
《北京大学学报(自然科学版)》2014年第3期411-415,共5页陈梅 张路 许进 
国家自然科学基金(60974112;60910002和60971085)资助
利用Riboswitch调控原理,在大肠杆菌BL21(DE3)菌株中构建一个细胞与门。该与门以实验室常见的阿拉伯糖和异丙基-β-D-硫代吡喃半乳糖苷(IPTG)为输入信号,黄色荧光蛋白YFP为输出信号,流式细胞仪检测结果显示该细胞与门成功地实现与逻辑...
关键词:生物分子计算 逻辑门 大肠杆菌BL21(DE3)菌株 核糖开关 
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