塞克肽类(Sactipeptide)天然产物的研究进展  

Current Advancements in Sactipeptide Natural Products

作　　者：陈允亮 李国权[2] 杨云鹏[3] 贾卫东[1] 施爱平[1] 张琪[4] CHEN Yun-Liang;LI Guo-Quan;YANG Yun-Peng;JIA Wei-Dong;SHI Ai-Ping;ZHANG Qi(School of Agricultural Equipment Engineering,Jiangsu University,Zhenjiang 212013,China;School of Food and Biological Engineering,Jiangsu University Zhenjiang 212013,China;Laboratory Animal Platform,Institute of Neuroscience,Chinese Academy of Sciences,Shanghai 200031,China;Department of Chemistry,Fudan University,Shanghai 200031,China)

机构地区：[1]江苏大学农业装备工程学院,镇江212013 [2]江苏大学食品与生物工程学院,镇江212013 [3]中国科学院神经科学研究所实验动物平台,上海200031 [4]复旦大学化学系,上海200433

出　　处：《生物化学与生物物理进展》2020年第10期1032-1045,共14页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(31400083,21822703);镇江市重点研发计划(NY2018015);丹徒区重点研发计划(NY2017001)资助项目。

摘　　要：塞克肽是一类重要的核糖体肽天然产物,具有多种生物活性,它们的共同特征是存在由半胱氨酸巯基与受体氨基的α-碳原子连接的分子内硫醚键.本篇综述总结了近年来塞克肽的发现、活性、生物合成、作用机制等多方面的工作,详细讨论了由SAM自由基酶介导的硫醚键形成机制.Sactipeptides represent an emerging class of ribosomally synthesized and post-translationally modifiedpeptides with diverse bioactivities.The common hallmark of sactipeptides is intramolecular thioether bond that crosslinks the sulfur atom of a cysteine and anα-carbon of an acceptor amino acid.This review summarizes recent achievements in many aspects of sactipeptides,including discovery,activity,biosynthesis,and mode of action,with a particular focus on the common enzymology of radical SAM chemistry leading to the unusual S-to-Cαthioether linkages.

关 键 词：塞克肽 核糖体肽 硫醚键 SAM自由基酶 

分 类 号：Q5[生物学—生物化学] Q7