电针对周围性面神经炎患者TLR4/NF-κB信号通路的影响  

Effect of electroacupuncture on TLR4/NF-κB signaling pathway in patients with peripheral facial neuritis

作　　者：姜曌 张晓杰 张文娟 李德帅 夏峰 JIANG Zhao;ZHANG Xiao-jie;ZHANG Wen-juan;LI De-shuai;XIA Feng(Department of Neurology,Xijing Hospital of Air Force Military Medical University,Xi’an 710032;Department of Neurology Ward 16,Xianyang Hospital of Yan an University,Xianyang 712000,Shaanxi,China)

机构地区：[1]空军军医大学西京医院神经内科,陕西西安710032 [2]延安大学咸阳医院神经内科十六病区,陕西咸阳712000

出　　处：《川北医学院学报》2020年第5期759-762,共4页Journal of North Sichuan Medical College

基　　金：陕西省科技统筹创新工程计划项目(2016KTZDSF02-06-02)。

摘　　要：目的:探究电针对周围性面神经炎患者Toll样受体4(TLR4)/核转录因子κB(NF-κB)信号通路的影响。方法:将118例周围性面神经炎患者随机分为两组,每组各59例。两组均采用基础治疗,观察组联合电针治疗。于治疗前(T0)、治疗1周(T1)、治疗2周(T2)、治疗3周(T3)时对两组患者的TLR4 mRNA及蛋白表达、NF-κB p65磷酸化水平进行比较,并比较治疗后两组临床疗效及治疗前、后的House-Brackmann面神经分级。结果:T1~T3时刻观察组患者TLR4 mRNA及蛋白表达均低于T0时刻,且均呈现下降趋势,观察组均低于对照组,差异有统计学有意义(P<0.05);T1~T3时刻观察组患者的NF-κB p65磷酸化水平低于T0时刻,且呈现下降趋势,观察组均低于对照组,差异有统计学意义(P<0.05);治疗后观察组患者临床愈显率与总有效率分别为89.83%和94.92%,均高于对照组的69.49%和84.74%,差异有统计学意义(P<0.05);治疗后观察组的House-Brackmann面神经分级情况优于对照组,差异有统计学意义(P<0.05)。结论:周围性面神经炎患者通过电针治疗,可以下调TLR4/NF-κB的表达,提高临床疗效,改善面部神经功能。Objective:To investigate the effect of electroacupuncture on Toll-like receptor 4(TLR4)/nuclear transcription factor kappaB(NF-κB)signaling pathway in patients with peripheral facial neuritis.Methods:118 cases of peripheral facial neuritis patients were studied and randomly divided into two groups,59 cases in each group.Both groups used basic treatment,and the observation group combined with electroacupuncture treatment.Before treatment(T0),treatment 1w(T1),treatment 2w(T2),treatment 3w(T3),the TLR4 mRNA and protein expression,NF-κB p65 phosphorylation level of the two groups were compared,the clinical efficacy of the two groups after treatment and the House-Brackmann facial nerve grading before and after treatment were compared.Results:The expressions of TLR4 mRNA and protein in the observation group at T1~T3 were lower than those at T0,and they all showed a downward trend.The observation group was lower than the control group,the difference was statistically significant(P<0.05).The phosphorylation level of NF-κB p65 in the observation group at T1~T3 was lower than that at T0,and showed a downward trend.The levels of NF-κB p65 phosphorylation in the observation group were lower than those in the control group,and the difference was statistically insignificant(P<0.05).After treatment,the clinical cure rate and total effective rate of patients in the observation group were 89.83%and 94.92%,which were higher than the control group s 69.49%and 84.74%,the differences were statistically significant(P<0.05).The House-Brackmann facial nerve grading of the observation group after treatment was superior to the control group,and the difference was statistically significant(P<0.05).Conclusion:Patients with peripheral facial neuritis can reduce the expression of TLR4/NF-κB through electroacupuncture treatment,improve clinical efficacy,and improve facial nerve function.

关 键 词：周围性面神经炎 电针 TOLL样受体4 核转录因子KB 

分 类 号：R745.1[医药卫生—神经病学与精神病学] R287.1[医药卫生—临床医学]