阿戈美拉汀联合阿立哌唑治疗重度抑郁症的临床效果  

Clinical effect of Agomelatine combined with Aripiprazole in the treatment of major depressive disorder

作　　者：梁晓玲 秦君 LIANG Xiao-ling;QIN Jun(Department of Pharmacy,Qingdao Mental Health Center,Qingdao University,Shandong Province,Qingdao266000,China;the Third Department of Psychiatry,Qingdao Mental Health Center,Qingdao University,Shandong Province,Qingdao266000,China)

机构地区：[1]青岛市精神卫生中心药剂科,青岛大学,山东青岛266000 [2]青岛市精神卫生中心精神三科,青岛大学,山东青岛266000

出　　处：《中国当代医药》2020年第29期74-76,共3页China Modern Medicine

摘　　要：目的探讨阿戈美拉汀联合阿立哌唑治疗重度抑郁的临床效果及安全性。方法选取2019年1~12月我院收治的62例重度抑郁症患者,按照随机数字表法分成观察组和对照组,各31例。两组均给予阿戈美拉汀25~50 mg/d治疗,夜间服药。在此基础上,观察组给予阿立哌唑10~15 mg/d,晨间服用;对照组给予外观相似的安慰剂,加量方法同阿立哌唑,持续治疗6周。比较两组临床疗效,比较治疗前和治疗第2、4、6周汉密尔顿抑郁量表(HAMD)评分和副作用量表(TESS)评分。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗前的HAMD评分比较,差异无统计学意义(P>0.05);治疗后两组各时间点的HAMD评分低于治疗前,差异有统计学意义(P<0.05);且观察组第4、6周的HAMD评分低于对照组,差异有统计学意义(P<0.05)。不良反应包括头晕头痛头晕、失眠、恶心、嗜睡、口干、心动过速、一过性肝功异常,两组各不良反应发生率比较,差异均无统计学意义(P>0.05)。结论阿戈美拉汀联合阿立哌唑治疗重度抑郁的效果更佳,症状改善更明显,且不良反应无明显增加,具有积极的临床意义,值得推广。Objective To investigate the clinical effect and safety of Agomelatine combined with Aripiprazole in the treatment of major depressive disorder.Methods A total of 62 patients with major depressive disorder admitted to our hospital from January to December 2019 were divided into observation group and control group with 31 cases in each group according to the random principle.The patients in both groups were given 25-50 mg/d Agomelatine and taken at night.On this basis,the patients in observation group were given Aripiprazole 10-15 mg/d in the morning;the patients in control group were given placebo with similar appearance,the dosage method was the same as Aripiprazole,and the treatment lasted for 6 weeks.The clinical effect,HAMD score and TESS were compared before treatment and at the 2nd,4th and 6th week of treatment.Results The effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the HAMD scores between the two groups before treatment(P>0.05);the HAMD scores of the two groups at each time point after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05);the HAMD scores of 4 weeks and 6 weeks were lower than those of the control group,and the differences were statistically significant(P<0.05).Adverse reactions include dizziness,headache,dizziness,insomnia,nausea,drowsiness,dry mouth,tachycardia,and transient liver function abnormalities,there was no statistically significant difference between the two groups of the incidence of adverse reactions(P>0.05).Conclusion The combination of Agomelatine and Aripiprazole is more effective in the treatment of major depressive disorder,the improvement of symptoms is more obvious,and there is no significant increase in adverse reactions,which has positive clinical significance and is worth promoting.

关 键 词：阿戈美拉汀 阿立哌唑 重度抑郁症 不良反应 

分 类 号：R749.503[医药卫生—神经病学与精神病学]