表柔比星在外周神经阻滞注射治疗原发性三叉神经痛中的临床观察  

The clinical curative efficacy of epirubicin peripheral nerve block in the treatment of primary trigeminal neuralgia

作　　者：蒋琳 杨勇 黄文泉[1] 崔美玲 邵益森[1] 王伟[1] JIANG Lin;YANG Yong;HUANG Wenquan(Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang,Jiangxi Province,330006,China;Department of Stomatology,Gongqingcheng People’s Hospital,Gongqingcheng,Jiangxi Province,332020,China)

机构地区：[1]江西中医药大学附属医院口腔创伤整形科,南昌330006 [2]江西省共青城市人民医院口腔科,共青城332020

出　　处：《江西医药》2020年第10期1383-1384,1395,共3页Jiangxi Medical Journal

基　　金：江西省卫生计生委科技计划课题,编号20195350;江西省教育厅课题,编号170709;江西省自然科学基金面上项目,编号20181BAB205039。

摘　　要：目的评价表柔比星在外周神经阻滞注射治疗原发性三叉神经痛的临床效果。方法回顾性分析我科2014年7月至2019年6月收治的21例原发性三叉神经痛患者的临床资料,均使用表柔比星外周神经阻滞治疗,记录治疗前,治疗后2周、1个月、3个月、6个月和12个月的疼痛视觉模拟评分(visual analogue scale,VAS),评价临床治疗效果。结果采用表柔比星治疗前VAS评分为(8.52±0.93),治疗后2周、1个月、3个月、6个月和12个月的VAS评分分为(4.48±1.60),(4.29±1.31),(3.95±1.56),(3.81±1.47)和(3.48±1.40),与治疗前相比,治疗后VAS评分均下降,差异具有统计学意义(P<0.05);采用表柔比星治疗后痊愈5例(23.81%),显效12例(57.14%),无效4例(19.05%),其有效率为80.95%。结论表柔比星用于外周神经阻滞治疗原发性三叉神经痛,是一种安全有效的方法。Objective To study the clinical effect of epirubicin in the treatment of primary trigeminal neuralgia.Methods A total of 21 patients with primary trigeminal neuralgia admitted to our department from July 2014 to June 2019 were selected,all the patients were given a dose-injection treatment with epirubicin,the VAS(visual analogue scale)scores were recorded before treatment,2 weeks,1 month,3 months,6months and 12months after treatment to evaluate the clinical treatment effect.Results The VAS score before treatment with epirubicin was(8.52±0.93).The VAS scores at 2 weeks,1 month,3 months,6months and 12months after treatment were(4.48±1.60),(4.29±1.31),(3.95±1.56),(3.81±1.47)and(3.48±1.40)respectively.Compared with that before treatment,all VAS scores after treatment were decreased,with statistically significant differences(P<0.05).After treatment with epirubicin,5 cases(23.81%)were cured,12 cases(57.14%)were markedly effective,and 4 cases(19.05%)were ineffective.The effective rate was 80.95%.Conclusion Epirubicin is an effective method for the treatment of primary trigeminal neuralgia.

关 键 词：表柔比星 三叉神经痛 视觉模拟评分 

分 类 号：R745.11[医药卫生—神经病学与精神病学]