动态工况下SPF级实验兔饲养微环境模拟分析  

Simulation analysis of feeding microenvironment of specific pathogen free experimental rabbits under dynamic operation

作　　者：龚光彩[1] 陈盟君 安珂慧 刘激扬 石星 GONG Guangcai;CHEN Mengjun;AN Kehui;LIU Jiyang;SHI Xing(College of Civil Engineering,Hunan University,Changsha 410082,China)

机构地区：[1]湖南大学土木工程学院,长沙410082

出　　处：《中国比较医学杂志》2020年第10期99-106,共8页Chinese Journal of Comparative Medicine

基　　金：国家科技支撑计划(2015BAJ03B01)。

摘　　要：目的本研究对SPF级实验动物房动态工况下的大环境与饲养微环境参数的展开对比分析,以探讨饲养微环境对实验动物的影响。方法建立实验兔等温体表生物传热模型与托盘散湿散氨模型,通过CFD模拟对比分析静态与动态工况下实验动物房的大环境与饲养微环境。结果加入实验兔之后的实验动物房大环境变化不明显,而笼架处及微环境内的气流流动更加混乱,导致传热传湿及污染物的排出受到影响,部分微环境参数值可能超过标准。结论得到了静态及动态工况下环境因素的变化情况,控制饲养微环境状态更能保证实验动物的福利及质量。Objective The study aim was to explore the effect of feeding microenvironment on laboratory animals.Macroenvironment and microenvironment parameters were compared under the dynamic operation of a specific pathogen free laboratory animal room.Methods An isothermal body surface heat transfer model and a tray moisture and ammonia model were established in rabbits,and the laboratory animal room environment under static and dynamic operation were compared and analyzed using computational fluid dynamic simulation.Results The dynamic environment of the laboratory animal room under dynamic operation was not obvious,but the air flow of the microenvironment changed,resulting in heat dissipation,moisture dissipation,and exclusion of pollutants.Some microenvironment parameters may exceed the standard.Conclusions Changes in environmental factors under static and dynamic operation were observed.Enhanced control of the breeding microenvironment status could ensure the welfare and quality of laboratory animals.

关 键 词：饲养微环境 动态运行 生物传热模型 日本大耳兔 

分 类 号：R-33[医药卫生]