Ⅲ期胃、肠癌患者根治术后静脉联合腹腔热灌注化疗的安全性及疗效研究  

Safety and efficacy of intravenous combined with peritoneal hyperperfusion chemotherapy after radical operation in patients with gastric and colorectal cancer Phase Ⅲ

作　　者：罗文娟[1] 税莲[1] 邓成凤 苏州[1] 刘广国[1] 张黎 Luo Wenjuan;Shui Lian;Deng Chengfeng;Su Zhou;Liu Guangguo;Zhang Li(Department of Oncology,Sichuan Mianyang 404 Hospital(The Second Affiliated Hospital of North Sichuan Medical Colleage),Mianyang,Sichuan,621000,China)

机构地区：[1]四川绵阳四0四医院肿瘤科(川北医学院附属第二医院肿瘤科),四川绵阳621000

出　　处：《当代医学》2020年第31期101-104,共4页Contemporary Medicine

基　　金：四川省医学会科研课题计划(S15067);绵阳市卫生和计划生育委员会(201505)。

摘　　要：目的观察Ⅲ期胃、肠癌患者根治术后行静脉联合腹腔热灌注化疗的安全性及疗效。方法选取2014年4月至2018年2月本院收治的60例Ⅲ期胃、肠癌根治术后患者,随机分为静脉+腹腔灌注组及静脉组,每组30例。静脉+腹腔灌注组采用奥沙利铂腹腔热灌注联合氟尿嘧啶静脉输注的给药方式。静脉组采用奥沙利铂+氟尿嘧啶静脉输注的方式。比较两组治疗后KPS评分、不良反应发生率以及复发情况。结果静脉+腹腔灌注组KPS评分升高比例为83.34%,显著高于静脉组的56.66%,差异具有统计学意义(P<0.05)。静脉+腹腔灌注组恶心、呕吐、纳差,骨髓抑制,外周神经毒性发生率均低于静脉组,差异具有统计学意义(P<0.05);静脉+腹腔灌注组肠梗阻发生率高于静脉组,差异具有统计学意义(P<0.05)。两组便秘、肝损害发生率比较差异无统计学意义;两组均无腹泻发生。两组间术后1年复发率比较差异无统计学意义,静脉+腹腔灌注组术后2年复发率显著低于静脉组,差异具有统计学意义(P<0.05)。结论Ⅲ期胃、肠癌患者根治术后行静脉联合腹腔热灌注化疗疗效确切,安全性较好,患者耐受性好,且能明显降低中长期复发率。Objective To observe the safety and efficacy of intravenous combined intraperitoneal hyperthermic chemotherapy in patients with stage Ⅲ gastric and intestinal cancer. Methods 60 patients with stage Ⅲ gastric and intestinal cancer who underwent radical gastrectomy in our hospital from April 2014 to February 2018 were randomly divided into intravenous + abdominal perfusion group and intravenous group, with 30 cases in each group. The intravenous+intraperitoneal infusion group used oxaliplatin intraperitoneal hot perfusion combined with intravenous infusion of fluorouracil. In the intravenous group, oxaliplatin+fluorouracil intravenous infusion was used. The KPS score, incidence of adverse reactions and recurrence after treatment were compared between the two groups. Results The increase rate of KPS score in the venous+peritoneal perfusion group was83.34%, which was significantly higher than the 56.66% in the intra venous group, and the difference was statistically significant(P<0.05). The incidence of nausea, vomiting and anorexia, bone marrow suppression, and peripheral neurotoxicity in the intravenous + intraperitoneal perfusion group were lower than that in the intravenous group, and the difference was statistically significant(P<0.05). The incidence of intestinal obstruction in the intravenous+intraperitoneal perfusion group was higher than that in the intravenous group, and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of constipation and liver damage between the two groups. No diarrhea occurred in both groups.There was no statistically significant difference in the 1-year postoperative recurrence rate between the two groups, the 2-year postoperative recurrence rate in the venous+intraperitoneal perfusion group was significantly lower than that in the venous group,and the difference was statistically significant(P<0.05). Conclusion In patients with stage Ⅲ gastric and intestinal cancer, intravenous combined with intraperitoneal hyperthermic chem

关 键 词：期胃肠癌术后 腹腔热灌注 静脉化疗 不良反应 

分 类 号：R735[医药卫生—肿瘤]