中老年男性脑卒中高危人群血尿酸、低密度脂蛋白胆固醇与颈动脉粥样硬化斑块的相关性  

Correlation between serum uric acid, low density lipoprotein cholesterol and carotid atherosclerotic plaque in middle-aged and elderly men with high risk of stroke

作　　者：焦义明[1] 何健玲[1] 薛孟周 JIAO Yiming;HE Jianling;XUE Mengzhou(Department of Cerebrovascular Disease,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,Henan,China)

机构地区：[1]郑州大学第二附属医院脑血管病科,河南郑州450014

出　　处：《延边大学医学学报》2020年第2期97-101,共5页Journal of Medical Science Yanbian University

基　　金：国家自然科学基金面上项目(81471174,81870942);国家自然科学基金重点国际(地区)合作研究项目(81520108011);国家重点研发计划(2018YFC1312200);河南省创新型科技人才队伍建设工程支持。

摘　　要：[目的]探讨中老年男性脑卒中高危人群血尿酸、低密度脂蛋白胆固醇与颈动脉粥样硬化(CAS)斑块的相关性.[方法]采用问卷调查、实验室检测及颈部血管彩色超声波检查等方法筛选出自2016年4月至2019年4月间进行体格检查的中老年男性脑卒中高危人群1 500例,依据血尿酸三分位数及低密度脂蛋白内科分层标准分为正常组(474例)、临界组(501例)和异常组(575例),同时又根据CAS斑块检测结果分为颈动脉稳定斑块组(n=216)、颈动脉软斑块组(n=754)和颈动脉无斑块组(n=530).[结果]正常组、临界组、异常组男性年龄、体质量指数、吸烟史、饮酒史、脑卒中家族史、糖尿病史构成比及空腹血糖(FBG)、收缩压值间差异均有统计学意义(P<0.05).与颈动脉稳定斑块组和颈动脉无斑块组比较,颈动脉软斑块组年龄、FBG、同型半胱氨酸、血尿酸、低密度脂蛋白水平均明显升高(P<0.05).多元Logistic回归分析结果显示,临界组和异常组颈动脉软斑块形成风险分别是正常组的1.31倍(P<0.01)和1.72倍(P<0.01).[结论]中老年男性脑卒中高危人群血尿酸、低密度脂蛋白水平升高,尤其是二者同时升高与CAS软斑块的形成密切相关.OBJECTIVE To investigate the correlation between serum uric acid, low density lipoprotein cholesterol(LDL-C) and carotid atherosclerotic(CAS) plaque in middle-aged and elderly men with high risks of stroke. METHODS A total of 1 500 middle-aged and elderly men with high risk of stroke who underwent physical examination between April 2016 and April 2019 were screened by questionnaires, laboratory test and cervical vascular color ultrasound. The patients were divided into the normal group(474 cases), the critical group(501 cases) and the abnormal group(575 cases) according to the serum uric acid tertile and LDL-C internal medicine stratification standard. At the same time, according to the CAS plaque detection results, the patients were divided into carotid artery stable plaque group(n=216), carotid soft plaque group(n=754), and carotid plaque-free group(n=530). RESULTS There were statistically significant differences in age, BMI, smoking history, drinking history, family history of stroke, diabetes history, fasting blood glucose(FBG) and systolic blood pressure between the normal, the critical and the abnormal group(P<0.05). The age, FBG, homocysteine(Hcy), serum uric acid and LDL level were significantly increased in carotid soft plaque group compared with carotid artery stable plaque group and carotid plaque-free group(P<0.05). Multivariable logistic regression analysis results showed that the risk of carotid artery plaque formation in the critical and abnormal group was 1.31 times(P<0.01) and 1.72 times(P<0.01), respectively, compared with the normal group. CONCLUSION The increase of serum uric acid level and LDL level, especially simultaneous increase of them, in middle-aged and elderly men with high risk of stroke are closely related to the formation of CAS soft plaque.

关 键 词：颈动脉粥样硬化 软斑块 尿酸 低密度脂蛋白 脑卒中高危人群 中老年男性 

分 类 号：R743[医药卫生—神经病学与精神病学]