STC2蛋白在子宫内膜癌中的表达及其与预后的关系  

Expression of STC2 protein in endometrial cancer and its relationship with prognosis

作　　者：周蔚 戴晓云[1] 王中海[1] ZHOU Wei;DAI Xiao-yun;WANG Zhong-hai(Department of Obstetrics and Gynecology,Shenzhen Nanshan People′s Hospital,Shenzhen Gaungdong 518052,China)

机构地区：[1]广东省深圳市南山区人民医院妇产科,518052

出　　处：《蚌埠医学院学报》2020年第10期1384-1386,1391,共4页Journal of Bengbu Medical College

摘　　要：目的:研究斯钙素2(STC2)蛋白在子宫内膜癌中的表达,探讨STC2表达水平与子宫内膜癌预后的关系。方法:收集子宫内膜癌病人的手术标本78例,运用免疫组织化学法检测样本中STC2蛋白表达;分析STC2蛋白水平与病人临床特征的关系。比较STC2不同表达程度与无复发生存率的关系。结果:对所有手术标本进行STC2免疫组织化学染色,发现有STC2阳性的肿瘤细胞的样本共61件,占所有样本的65.38%。根据STC染色结果评分标准,STC2无表达+低表达组样本35件(44.87%),STC2高表达组样本43件(55.13%)。2组病人年龄比较差异无统计学意义(P>0.05),但高表达组的FIGO分期、侵犯淋巴血管、侵犯子宫肌层以及累及子宫颈较无表达+低表达组明显加重,差异均有统计学意义(P<0.05~P<0.01)。对所有病人术后随访1~24个月,随访期间共有14例(17.95%)病人出现肿瘤复发,其中无表达+低表达组2例(5.71%),高表达组12例(27.91%)。2组病人随访期间的无复发生存率比较STC2高表达组低于无表达+低表达组,差异有统计学意义(P<0.05)。结论:大部分子宫内膜癌均表达有轻-中度的STC2蛋白,而STC2高表达与疾病的预后不良有很大的关系,其可能用以作为子宫内膜癌预后的预测指标。Objective:To investigate the expression levels of stanniocalcin-2(STC2)protein in endometrial cancer and its relationship with prognosis.Methods:A total of 78 samples of endometrial cancer were collected.The expression level of STC2 protein in all cases were measured using immunohistochemistry,and the correlation of which with clinical characteristics was analyzed.The relationship between STC2 expression level and relapse-free survival rate was compared.Results:The results of immunohistochemistry showed that the tumor cells with positive STC2 staining in 61 samples were found,which accounted for 65.38%.Based on staining score system,the non-or low-expression of STC2 in 35 samples(44.87%)and high-expression of STC2 in 43 samples(55.13%)were identified.There was no statistical significance in the age between two groups(P>0.05),but the FIGO staging,lymphatic vascular invasion,myometrium invasion and cervical involvement in high-expression group significantly aggravated compared with the non-expression and low-expression group,and the difference of which was statistically significant(P<0.05 to P<0.01).All patients were followed up for 12 months.During the following-up,the tumor recurrence in 14 cases(17.95%)found,which included 2 cases(5.71%)in non-or low-expression group and 12 cases(27.91%)in high-expression group.The relapse-free survival rate in high-expression group was lower than that in non-or low-expression group(P<0.05).Conclusions:There is light-moderate STC2 expression in most cases of endometrial cancer,and its high expression level is associated with the poor prognosis.STC2 may be a prediction marker for the prognosis of endometrial cancer.

关 键 词：子宫内膜肿瘤 斯钙素2 预后 

分 类 号：R737.33[医药卫生—肿瘤]