巴曲酶对脑栓塞后患者的治疗情况及对血清VEGF水平、血栓弹力图指标的影响  

Effect of Batroxobin on the Treatment of Patients after Cerebral Embolism and Its Influence on Serum VEGF Level and Thromboelastography Indexes

作　　者：梁健平 朱岳鑫 黄国争 杨良转 LIANG Jianping;ZHU Yuexin;HUANG Guozheng;YANG Liangzhuan(The People’s Hospital of Yangdong District in Yangjiang City,Yangjiang 529500,China;不详)

机构地区：[1]广东省阳江市阳东区人民医院,广东阳江529500 [2]广东省中医院

出　　处：《中国医学创新》2020年第29期34-37,共4页Medical Innovation of China

摘　　要：目的:分析巴曲酶对脑栓塞后患者的治疗情况及对血清血管内皮生长因子(VEGF)水平、血栓弹力图指标的影响。方法:选取2016年2月-2018年2月本院收治的脑栓塞后患者78例。根据治疗方法不同分为对照组和观察组,每组39例。对照组患者采用常规治疗,观察组在对照组基础上加用巴曲酶治疗,分析两组患者的治疗情况及血栓弹力图指标水平。结果:治疗前,两组患者FIB、hs-CRP、VEGF、AngⅡ、vWF水平、血栓弹力图指标及神经功能缺损评分比较,差异均无统计学意义(P>0.05);治疗7、14 d后,观察组的VEGF水平均高于对照组,FIB、hs-CRP、AngⅡ、vWF水平及神经功能缺损评分均低于对照组,差异均有统计学意义(P<0.05)。治疗14 d后,观察组的R、K值均高于对照组,α角、MA均低于对照组,差异均有统计学意义(P<0.05)。结论:巴曲酶治疗脑栓塞可降低患者FIB、AngⅡ水平,提高患者VEGF水平,改善患者凝血功能。Objective:To analyze the therapeutic effect of Batroxobin on patients after cerebral embolism and its influence on the levels of serum vascular endothelial growth factor(VEGF)and thromboelastography indexes.Method:A total of 78 patients after cerebral embolism admitted to our hospital from February 2016 to February 2018 were selected.According to different treatment methods,the patients were divided into control group and observation group,39 cases in each group.The patients in the control group were given conventional treatment,the observation group was treated with Batroxobin on the basis of the control group.The treatment and thrombotic elasticity map were compared between the two groups.Result:Before treatment,there were no significant differences in FIB,hs-CRP,VEGF,AngⅡ,vWF levels,thromboelastography indexes and neurological deficit score between the two groups(P>0.05).After 7 and 14 d of treatment,VEGF levels in the observation group were higher than those in the control group,FIB,hs-CRP,AngⅡ,vWF levels and neurological deficit score were lower than those in the control group,the differences were statistically significant(P<0.05).After 14 d of treatment,the R and K values of the observation group were higher than those of the control group,theαangle and MA were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Batroxobin treatment of cerebral embolism can reduce the level of FIB and AngⅡ,increase the level of VEGF,and improve the coagulation function of patients.

关 键 词：巴曲酶 脑栓塞 血管内皮生长因子 血栓弹力图 

分 类 号：R743.3[医药卫生—神经病学与精神病学]