急性缺血性脑血管病患者静脉溶栓后强化他汀治疗分析  

Analysis of Intensive Statin Therapy in Patients with Acute Ischemic Cerebrovascular Disease after Intravenous Thrombolysis

作　　者：上官亚菲[1] 张艳[1] 范玉兰 熊涛[1] 刘承灵 SHANGGUAN Ya-fei;ZHANG Yan;FAN Yu-lan;XIONG Tao;LIU Cheng-ling(Department of Neurology,Guiyang First People's Hospital,Guiyang,Guizhou Province,550002 China)

机构地区：[1]贵阳市第一人民医院神经内科,贵州贵阳550002

出　　处：《中外医疗》2020年第27期99-101,共3页China & Foreign Medical Treatment

摘　　要：目的探讨急性缺血性脑血管病患者静脉溶栓后强化他汀治疗分析。方法随机选取2017年1月—2019年12月在该院神经内科治疗的60例急性缺血性脑血管病患者,随机分为两组,对比两组的预后、神经功能、炎性因子水平变化、出血并发症发生情况。结果观察组预后良好率为83.33%明显高于对照组的63.33%,差异有统计学意义(χ^2=3.968,P<0.05),mRS评分明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后NIHSS评分明显低于对照组,而BI指数明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后hs-CRP、MMP-9、IL-6、IL-8水平明显低于对照组,差异有统计学意义(P<0.05);观察组溶栓后出血转化、脑实质出血、症状性颅内出血等发生率均明显低于对照组,差异有统计学意义(P<0.05)。结论急性缺血性脑血管病患者静脉溶栓后强化他汀治疗效果显著,能有效改善患者预后,促进神经功能的修复和改善,降低炎症反应对脑组织的损伤,减少溶栓后出血几率,具有积极的临床意义。Objective To investigate the analysis of intensified statin therapy in patients with acute ischemic cerebrovascular disease after intravenous thrombolysis.Methods Sixty patients with acute ischemic cerebrovascular disease treated in the Department of Neurology of the hospital from January 2017 to December 2019 were randomly convenienty selected and divided into two groups,and the prognosis,nerve function,changes in inflammatory factor levels,and hemorrhage complications occurrence of the two groups were compared.Results The good prognosis rate of the observation group was 83.33%significantly higher than that of the control group 63.33%,the difference was statistically significant(χ^2=3.968,P<0.05),and the mRS score was significantly higher than that of the control group,the difference was statistically significant(P<0.05);treatment of the observation group After NIHSS score was significantly lower than the control group,and the BI index was significantly higher than the control group,the difference was statistically significant(P<0.05);the observation group after treatment hs-CRP,MMP-9,IL-6,IL-8 levels were significantly lower than the control group,the difference was statistically significant(P<0.05);the incidence of hemorrhage transformation,cerebral parenchymal hemorrhage,and symptomatic intracranial hemorrhage after thrombolysis in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion After intravenous thrombolysis in patients with acute ischemic cerebrovascular disease,the enhanced statin therapy has a significant effect,which can effectively improve the prognosis of patients,promote the repair and improvement of nerve function,reduce the damage of inflammation to brain tissue,and reduce the chance of bleeding after thrombolysis,with positive clinical significance.

关 键 词：急性缺血性脑血管病 静脉溶栓 强化他汀治疗 预后 神经功能 

分 类 号：R743.31[医药卫生—神经病学与精神病学]