醒脑静注射液联合纳洛酮治疗重症脑梗塞伴昏迷患者的临床效果分析  

Clinical Effect Analysis of Xingnaojing Injection Combined with Naloxone in the Treatment of Patients with Severe Cerebral Infarction and Coma

作　　者：李永涛 LI Yong-tao(Department of Neurology,the Second People's Hospital of Chengyang District,Qingdao,Shandong Province,266112 China)

机构地区：[1]青岛市城阳区第二人民医院神经内科,山东青岛266112

出　　处：《系统医学》2020年第17期1-3,共3页Systems Medicine

摘　　要：目的讨论醒脑静注射液联合纳洛酮治疗重症脑梗塞伴昏迷患者的临床效果分析。方法选取2018年9月—2019年9月该院治疗的重症脑梗塞伴昏迷的患者100例,根据患者的入院时间顺序分为两组,在实验组中使用醒脑静注射液联合纳洛酮治疗,在对照组中使用纳洛酮治疗。比较两组的治疗效果,神经缺损评分,不良反应的情况。结果实验组中有4.00%的患者没有达到有效的标准,有24.00%的患者达到有效的标准,有72.00%的患者达到显效的标准。实验组总有效率高于对照组,差异有统计学意义(χ^2=8.148,P<0.05)。实验组的GCS评分高于对照组,差异有统计学意义(t=7.529,P<0.05)。对照组的神经缺损评分高于实验组,差异有统计学意义(t=7.118,P<0.05)。实验组中有1例患者发生恶心的症状,有1例患者发生心动过速的症状。对照组中有3例患者发生恶心的症状,有3例患者发生心动过速的症状,有2例患者发生胸闷。两组差异有统计学意义(χ^2=4.000,P<0.05)。结论在重症脑梗塞伴昏迷的患者中使用醒脑静注射液联合纳洛酮治疗,可以提高治疗效果,减少不良反应,改善神经功能,降低昏迷程度,具有重要的临床价值。Objective To discuss the clinical effect of Xingnaojing injection combined with naloxone in the treatment of patients with severe cerebral infarction and coma. Methods A total of 100 patients with severe cerebral infarction and coma treated in the hospital from September 2018 to September 2019 were selected and divided into two groups according to the time sequence of the patients’ admission. In the experimental group, Xingnaojing injection combined with Naloxone was used, naloxone treatment was used in the control group. The treatment effects, nerve defect scores,and adverse reactions of the two groups were compared. Results 4.00% of the patients in the experimental group did not meet the effective standard, 24.00% of the patients reached the effective standard, and 72.00% of the patients reached the effective standard. The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant(χ^2=8.148,P <0.05). The GCS score of the experimental group was higher than that of the control group, the difference was statistically significant(t=7.529,P<0.05). The nerve defect score of the control group was higher than that of the experimental group, the difference was statistically significant(t=7.118,P <0.05). In the experimental group, 1 patients had symptoms of nausea, and 1 patients had symptoms of tachycardia. In the control group, 3 patients had symptoms of nausea, 3 patients had symptoms of tachycardia, and 2 patients had chest tightness. The difference between the two groups was statistically significant (χ^2=4.000,P <0.05).Conclusion The use of Xingnaojing injection combined with naloxone therapy in patients with severe cerebral infarction and coma can improve the therapeutic effect, reduce adverse reactions, improve neurological function, and reduce the degree of coma, which has important clinical value.

关 键 词：醒脑静注射液 纳洛酮 重症脑梗塞伴昏迷 

分 类 号：R743.33[医药卫生—神经病学与精神病学]