无抽搐电休克联合抗精神病药物治疗精神分裂症住院患者的临床疗效  

Clinical efficacy of non-convulsive electric shock combined with anti-psychotic drugs in the treatment of hospitalized patients with schizophrenia

作　　者：冯玉宏 白义宝 黄文琴 FENG Yuhong;BAI Yibao;HUANG Wenqin(Department of Women′s Mental Health,The Fifth Hospital of Yulin City in Shaanxi Province,Yulin,Shaanxi,719000;Department of Psychiatry,The Fifth Hospital of Yulin City in Shaanxi Province,Yulin,Shaanxi,719000)

机构地区：[1]陕西省榆林市第五医院妇女心理卫生一科,陕西榆林719000 [2]陕西省榆林市第五医院精神科,陕西榆林719000

出　　处：《实用临床医药杂志》2020年第17期92-95,共4页Journal of Clinical Medicine in Practice

基　　金：陕西省卫生和计划委员会课题(S2016TFSF0376)。

摘　　要：目的观察精神分裂症住院患者应用无抽搐电休克联合抗精神病药物治疗的临床疗效。方法选择精神分裂症患者90例为研究对象,按照随机数字表法分为实验组和对照组,每组45例。对照组接受抗精神病常规药物治疗,实验组在对照组基础上联合无抽搐电休克治疗,2组均观察6周。比较2组临床疗效及认知功能变化情况。结果研究组临床总有效率为95.56%,显著高于对照组的80.00%(P<0.05)。治疗前,2组阴性与阳性症状量表(PANSS)评分差异无统计学意义(P>0.05);2组治疗1、3、6周后的PANSS评分均较治疗前显著降低(P<0.05),且实验组以上时点的PANSS评分均显著低于对照组(P<0.05)。治疗前,2组韦氏成人智力量表(WAIS-RC)评分差异无统计学意义(P>0.05);治疗6周后,2组WAIS-RC评分均较治疗前显著提高(P<0.05),且实验组显著高于对照组(P<0.05)。结论精神分裂症住院患者采用无抽搐电休克联合抗精神病药物治疗的临床疗效较好,能显著减轻药物导致的认知功能损伤程度,提高用药安全性及患者依从性。Objective To observe the clinical effect of non-convulsive electric shock combined with anti-psychotic drugs in treatment of hospitalized patients with schizophrenia. Methods A total of 90 patients with schizophrenia were selected as research objects,and were divided into experimental group( n = 45) and control group( n = 45) according to random number table method. The control group was treated with routine antipsychotic drugs,and the experimental group was treated with routine antipsychotic drugs combined with non-convulsive electric shock,both groups were observed for 6 weeks. The clinical efficacy and changes of cognitive function of the two groups were compared.Results The total clinical effective rate was 95. 56%,which was significantly higher than 80. 00%( P < 0. 05). There was no significant difference in Negative and Positive Symptom Scale( PANSS)score between the two groups before treatment( P > 0. 05);after 1 week 3 and 6 weeks of treatment,the PANSS scores of the two groups were significantly lower than those before treatment( P < 0. 05),and the experimental group was significantly lower than the control group( P < 0. 05). There was no significant difference in Wechsler Adult Intelligence Scale( WAIS-RC) score between the two groups before treatment( P > 0. 05);after 6 weeks of treatment,the WAIS-RC scores of both groups were significantly higher than before treatment( P < 0. 05),and the experimental group was significantly higher than that of the control group( P < 0. 05). Conclusion Non-convulsive electric shock combined with anti-psychotic drugs has better efficacy,which can significantly reduce the degree of cognitive function injury caused by drug,enhance safety and compliance.

关 键 词：抗精神病药物 无抽搐电休克 精神分裂症 阴性与阳性症状量表评分 韦氏成人智力量表评分 

分 类 号：R749.3[医药卫生—神经病学与精神病学]