未治疗抑郁症患者吸烟与抑郁症状及认知功能关系  

The relationship between smoking,depressive symptoms and cognitive function in untreated depressed patients

作　　者：张沐钦 周燕玲[1] 詹妍妮 刘伟健 施海姗[2] 黎伟城 张志沛 宁玉萍[1] ZHANG Muqin;ZHOU Yanling;ZHAN Yanni;LIU Weijian;SHI Haishan;LI Weicheng;ZHANG Zhipei;NING Yuping(Brain Hospital Affiliated to Guangzhou Medical University,Guangzhou 510370,China)

机构地区：[1]广州医科大学附属脑科医院精神科,广州510370 [2]广州医科大学附属脑科医院神经内科

出　　处：《中国神经精神疾病杂志》2020年第8期476-480,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：精准医学研究重点专项项目(编号:2016YFC0906300)。

摘　　要：目的研究未治疗的抑郁症患者吸烟与其抑郁症状及认知功能的关系。方法纳入未治疗的抑郁症患者211例,根据吸烟情况分为吸烟组50例、非吸烟组161例。使用尼古丁依赖严重程度量表对患者吸烟情况进行调查,使用17项汉密尔顿抑郁量表(the 17-item Hamilton depression rating scale, HAMD-17)评定患者的抑郁症状,使用MATRICS公认认知成套测验检测认知功能。结果吸烟组患者HAMD-17分高于非吸烟组(P<0.05);吸烟组连线测验得分高于非吸烟组(P<0.01),符号编码测验、言语记忆测验得分低于非吸烟组(均P<0.01)。吸烟组抑郁症状中的迟滞因子与每日吸烟量呈正相关(r=0.30,P=0.04),认知功能中符号编码测验与烟龄呈负相关(r=-0.39,P=0.01)。多因素线性回归分析显示,每日吸烟量与迟滞因子相关联(β=0.33,P=0.02),烟龄与认知功能中符号编码测验相关联(β=-0.49,P<0.01)。结论相比非吸烟的抑郁症患者,吸烟的抑郁症患者抑郁症状更重、认知功能受损更明显,提示吸烟可能是加重抑郁症症状及认知功能损害的危险因素。Objective To study the relationship between smoking and depressive symptoms and cognitive function in untreated depressed patients.Methods A total of 211 untreated depressed patients were enrolled.According to their smoking status,patients were divided into 50 cases in smoking group and 161 cases in non-smoking group.The Nicotine Dependence Severity Scale,the 17-item Hamilton Depression Rating scale(HAMD-17)and the MATRICS Recognition Test Package were used to investigate the smoking status of patients,to assess the patients’depressive symptoms,and to evaluate cognitive function.Results The scores of HAMD-17 in the smoking group were higher than those in the non-smoking group(P<0.05).The scores of the connection test in the smoking group were higher than those in the non-smoking group(P<0.01),and the scores of the symbol encoding test and the verbal memory test were lower than those in the non-smoking group(P<0.01).In the smoking group,the retardation factor of depression was positively correlated with the daily smoking amount(r=0.30,P=0.04),and the symbol coding test in cognitive function was negatively correlated with smoking age(r=-0.39,P=0.01).Multiple linear regression analysis showed that daily smoking is a risk factor of retardation(β=0.33,P=0.02);smoking age is a risk factor of the symbol coding test in cognitive function(β=-0.49,P<0.01).Conclusion Compared with non-smoking depression,the depressive symptoms and cognitive impairment of smoking patients are more severe,which suggests that smoking may be a risk factor for aggravating depression symptoms and cognitive impairment.

关 键 词：抑郁症 抑郁症状 吸烟 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]