海南儋州地区白内障患者角膜内皮细胞密度及形态特征观察  

Corneal endothelial cell density and morphology of cataract eyes in Danzhou city Hainan province

作　　者：黄静 杜雅莉[2] 张铭志[2] Huang Jing;Du Yali;Zhang Mingzhi(Department of Ophthalmology,Guangzhou Women and Children's Medical Center,Guangzhou 510000,China;Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong,Shantou 515041,China)

机构地区：[1]广州市妇女儿童医疗中心眼科,510000 [2]汕头大学·香港中文大学联合汕头国际眼科中心,汕头515041

出　　处：《中华实验眼科杂志》2020年第10期858-863,共6页Chinese Journal Of Experimental Ophthalmology

基　　金：广东省科技创新战略专项资金项目(汕府科[2018]157号);高水平大学建设计划临床医学重点建设学科专项资金项目。

摘　　要：目的探讨海南儋州地区白内障患者角膜内皮细胞密度和形态的影响因素。方法采用横断面研究方法,纳入2009年2—12月“亮睛工程”在海南儋州“亮睛点”儋州市第一人民医院收治的白内障患者573例573眼。采用TOPCON非接触式角膜内皮显微镜测量角膜内皮细胞密度、中央角膜厚度(CCT)、六角形细胞比例、内皮细胞面积等参数,比较不同性别、眼别和年龄组受检者上述各检测参数的差异,并分析其影响因素。结果海南儋州地区白内障患者平均角膜内皮细胞密度为(2533.00±366.67)个/mm 2,CCT为(501.15±31.67)μm。年龄、CCT、最大角膜内皮细胞面积、角膜内皮细胞面积标准差、角膜内皮细胞面积变异系数、角膜内皮六角形细胞比例、平均内皮细胞面积是角膜内皮细胞密度的主要影响因素,各年龄组间角膜内皮细胞密度比较差异均有统计学意义(均P<0.05),60~79岁组和≥80岁组患者角膜内皮细胞密度值小于60岁以下组,但≥80岁组角膜内皮细胞密度值大于60~79岁组,差异均有统计学意义(均P<0.01)。性别、角膜内皮细胞面积标准差、角膜内皮细胞面积变异系数、角膜内皮细胞密度是CCT的主要影响因素,男性CCT为(516.27±35.84)μm,明显高于女性的(492.20±24.97)μm,差异有统计学意义(t=89.205,P<0.01),不同性别间其他角膜内皮参数比较,差异均无统计学意义(均P>0.05)。不同眼别间角膜内皮各相关参数比较,差异均无统计学意义(均P>0.05)。结论海南儋州地区白内障患者角膜内皮细胞密度随年龄增长,角膜内皮细胞面积变异系数、平均角膜内皮细胞面积值增大,角膜内皮六角形细胞比例的减小而逐渐降低,60岁以上白内障患者角膜内皮细胞衰老速度存在差异。Objective To describe corneal endothelial cell density and morphology in cataract eyes in Danzhou city,Hainan province and analyze the influencing factors.Methods A cross-sectional study was performed.A total of 573 eyes of 573 cataract patients at Danzhou First People's Hospital,one of the Poverty Reduction Eye Centres of“Project Vision”,were enrolled from February to December in 2009.TOPCON non-contact corneal endothelial microscope was performed to measure the endothelial cell density,corneal central thickness(CCT),average endothelial cell area,maximum endothelial cell area,minimum endothelial cell area,cell area standard deviation,coefficient of variation in cell area,and percentage of hexagonality.The differences of the above parameters were compared among different genders,eyes and age groups,and the influencing factors were analyzed.This study followed the Declaration of Helsinki.Written informed consent was obtained from each subject prior to entering the study cohort.The study protocol was approved by the Ethics Committee of Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong(No.09-007).Results The average endothelial cell density of cataract patients was(2533.00±366.674)/mm 2(from 846 to 3969/mm 2),and the CCT was(501.150±31.666)μm.Age(P<0.01),CCT(P=0.013),maximum endothelial cell area(P=0.017),endothelial cell area standard deviation(P=0.011),coefficient of variation in endothelial cell area(P=0.001),percentage of hexagonality(P<0.01),and average endothelial cell area(P<0.01)were the major influencing factors of endothelial cell density.Endothelial cell density was significanly different in any two age groups(all at P<0.05).The endothelial cell density in cataract patients of 60-79 years old group and≥80 years old group was lower than that of<60 years old group,whereas the endothelial cell density in patients≥80 years old subgroups was higher than that in the 60-79 years subgroup,and the difference was statistically significant(all at P<0.01).

关 键 词：角膜 内皮细胞 角膜内皮细胞密度 生物学测量 影响因素 

分 类 号：R776.1[医药卫生—眼科]