术后PNI在胃癌患者预后评估中的临床价值  

Clinical value of postoperative PNI in prognosis assessment of gastric cancer patients

作　　者：吴平[1] 杜仁佳 俞筠 葛晓松[2] Wu Ping;Du Renjia;Yu Yun;Ge Xiaosong(Department of Clinical Nutrition,Affiliated Hospital of Jiangnan University,Wuxi 214062,Jiangsu,China;Department of Oncology,Affiliated Hospital of Jiangnan University,Wuxi 214062,Jiangsu,China)

机构地区：[1]江南大学附属医院临床营养科,江苏无锡214062 [2]江南大学附属医院肿瘤内科,江苏无锡214062

出　　处：《肿瘤代谢与营养电子杂志》2020年第3期312-316,共5页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家自然科学基金项目(81502042)。

摘　　要：目的探讨术后PNI在胃癌患者预后评估中的临床价值。方法回顾性分析术后胃癌Ⅲ期患者91例,根据术后、首次化疗前的外周血液指标计算出PNI、外周血中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、全身炎症指数(SII)等营养综合指标,通过ROC曲线计算出PNI最佳截断值。根据PNI最佳截断值将其分为低PNI组(PNI<42.3)和高PNI组(PNI≥42.3),根据PNI分组预测胃癌患者的预后。应用Cox回归模型进行单因素回归分析和多因素分析。结果多因素分析结果显示术后PNI(P=0.004)及分期(P=0.009)是影响胃癌患者总生存时间的独立预后因素。结论术后PNI是预测胃癌患者预后的独立因素,且低PNI和高分期与患者预后不良相关。Objective The prognostic nutritional index(PNI)is used as a prognostic factor in gastric cancer(GC).Through this retrospective study,we aim to investigate the relationship between the postoperative PNI and prognosis of patients with stageⅢGC.Methods The subjects of this retrospective study were 91 patients who underwent resection for stageⅢGC,according to the first chemotherapy after surgery,calculated nutrient comprehensive index,such as PNI,NLR,PLR,SII.Time-dependent receiver operating characteristic curve analyses were used to assess discrimination ability and to determine the optimal cut-off values.Results According to the optimal cut-off value,they were divided into the low PNI group(PNI<42.3)and the high PNI group(PNI≥42.3).According to the staging,they were divided intoⅢa,Ⅲb andⅢc three substages.All the inflammation-based and/or the nutritional markers of patients of stageⅢGC,multivariate analyses demonstrated PNI and staging were independent prognostic factors for OS(P=0.004 and P=0.009,respectively).Conclusion PNI is an independent prognostic factor for the prognosis of postoperative chemotherapy patients with gastric cancer,and low PNI and high sub-staging were associated with poor prognosis.

关 键 词：胃癌 术后预后营养指数 预后 

分 类 号：R735.2[医药卫生—肿瘤]