烷基化壳聚糖/多巴胺/氧化石墨烯粉末用于快速止血  

Alkylated chitosan/polydopamine/graphene oxide power for rapid hemostasis

作　　者：靳宁宁 苏丽[2] 高海军[3] 王莹[1] 李冰 张静[1] JIN Ningning;SU Li;GAO Haijun;WANG Ying;LI Bing;ZHANG Jing(School of Chemical Engineering,Zhengzhou University,Zhengzhou 450001,Henan,China;The Third People's Hospital of Zhengzhou,Zhengzhou 450001,Henan,China;School of Life Science,Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]郑州大学化工学院,河南郑州450001 [2]郑州市第三人民医院,河南郑州450001 [3]北京理工大学生命学院,北京100081

出　　处：《精细化工》2020年第10期2009-2014,共6页Fine Chemicals

基　　金：国家自然科学基金(81101748)。

摘　　要：壳聚糖(CS)及其衍生物价廉易得,止血性及生物相容性良好,广泛应用于抗菌、止血等材料的开发。用十二醛对壳聚糖(CS)进行N-烷基化改性制备烷基化壳聚糖(N-CS),在乙酸溶液中,将N-CS嵌入到多巴胺修饰的氧化石墨烯(DGO)骨架中制备出止血粉末(N-CS/DGO)。采用FTIR、SEM、BET和EDS对样品进行了表征。结果表明,N-CS/DGO止血粉末表面含有大量的活性基团,且具有优异的亲水性,大比表面积以及丰富的孔结构。DGO质量分数为15%的N-CS/DGO具有最佳止血性能,此材料的吸水率为430%,降解率在35d内可达到88%,对大肠杆菌和金黄色葡萄球菌抑菌环宽度分别为1.92和1.98 mm,具备一定抑菌能力,凝血指数达到最小值32%,体外凝血时间缩短至(126±6)s。因此,N-CS/DGO材料具备止血方面的潜力。Chitosan(CS)and its derivatives are widely used in the development of antibacterial and hemostatic materials due to their low price,easy to obtain,good hemostasis and biocompatibility.Alkylated chitosan(N-CS)was prepared by N-alkylation modification of CS with dodecanal.And then,N-CS was embedded into the skeleton of dopamine modified graphene oxide(DGO)in acetic acid solution to prepare hemostatic powders(N-CS/DGO).The samples were characterized by FTIR,SEM,BET and EDS.The results indicated that the surface of N-CS/DGO hemostatic powders contained a large number of active groups,and had excellent hydrophilicity,large specific surface area and rich pore structure.The composite N-CS/DGO powders with DGO mass fraction of 15%had the best performance for hemostasis.The material showed water absorption of 430%and appropriate degradation rate.The degradation rate could reach 88%in thirty-five days.Furthermore,the prepared powders exhibited certain bacteriostatic ability,and the antimicrobial ring widths for E.coli and S.aureus were 1.92 and 1.98 mm,respectively.The coagulation index could reach the minimum value(32%),and the coagulation time in vitro was shortened to(126±6)s.Therefore,N-CS/DGO powders have potential for hemostasis.

关 键 词：烷基化壳聚糖 氧化石墨烯 抑菌性 止血性能 功能材料 

分 类 号：R318.08[医药卫生—生物医学工程]