阻生智齿拔除术患者前后龈沟液中炎症因子和应激因子水平变化及临床意义  

Changes and Clinical Significance of Inflammatory Factors and Stress Factors in Gingival Crevicular Fluid of Patients Before and after Impacted Wisdom Tooth Extraction

作　　者：刘畅[1] 亓鹏[1] 张玉[1] 徐庆 夏娜[1] LIU Chang;QI Peng;ZHANG Yu;XU Qing;XIA Na(Department of Stomatology,Affiliated Hospital of Chengdu University,Chengdu,Sichuan,610081,China)

机构地区：[1]成都大学附属医院口腔科,四川成都610081

出　　处：《现代生物医学进展》2020年第18期3528-3531,共4页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研基金项目(110091)。

摘　　要：目的:探讨阻生智齿拔除术患者前后龈沟液中炎症因子和应激因子水平变化及临床意义。方法:选择我院2017年1月至2019年1月192例行阻生智齿拔除术的患者为研究对象(观察组),并选择100例口腔健康志愿者作为对照组,检测观察组阻生智齿拔除术术前、术后2d、术后5d及对照组龈沟液中白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、活性氧(ROS)水平,并在术后2d记录观察组患者牙龈指数(GI),探讨各指标与患者预后的关系。结果:观察组术前龈沟液IL-8、TNF-α、MDA及ROS水平与对照组无显著差异(P>0.05),术后2d、术后5d龈沟液IL-8、TNF-α、MDA及ROS水平均高于对照组(P<0.05);观察组术后2d龈沟液IL-8、TNF-α、MDA及ROS水平高于术前和术后5d(P<0.05),术后5d龈沟液IL-8、TNF-α、MDA及ROS水平高于术前(P<0.05);GI分级3级患者龈沟液IL-8、TNF-α、MDA及ROS水平高于GI分级2级患者,GI分级2级患者龈沟液IL-8、TNF-α、MDA及ROS水平高于GI分级1级患者(P<0.05);龈沟液IL-8、TNF-α、MDA及ROS水平与术后GI分级均呈正相关(P<0.05)。结论:阻生智齿拔除术患者手术前后龈沟液IL-8、TNF-α、MDA及ROS水平会出现波动,且术后各指标水平可反映患者预后情况。Objective:To explore the changes and clinical significance of inflammatory factors and stress factors in gingival crevicular fluid before and after extraction of impacted wisdom teeth extraction.Methods:A total of 192 patients with impacted wisdom tooth extraction from January 2017 to January 2019 in our hospital were selected as subjects(observation group),and 100 cases of oral health volunteers were selected as control group.The levels of interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA)and reactive oxygen species(ROS)in gingival crevicular fluid were detected in observation group before impacted wisdom tooth extraction and at 2 d,5 d after surgery and control group.The gingival index(GI)was recorded in observation group at 2 d after surgery,and the relationship between each index and prognosis was explored.Results:The levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid in observation group before surgery were not significantly different from those in control group(P>0.05),and the levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid at 2 d after surgery and at 5 d after surgery were higher than those in control group(P<0.05).The levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid in observation group at 2 d after surgery were higher than those before surgery and at 5 d after surgery(P<0.05),and the levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid at 5 d after surgery were higher than those before surgery(P<0.05).The levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid of patients with GI grade 3 were higher than those of patients with GI grade 2,and the levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid of patients with GI grade 2 were higher than those of patients with GI grade 1(P<0.05).The levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid were positively correlated with postoperative GI grade(P<0.05).Conclusion:The levels of IL-8,TNF-α,MDA and ROS in gingival crevicular fluid will fluctuate in patients b

关 键 词：阻生智齿拔除术 龈沟液 炎症因子 应激因子 牙龈指数 

分 类 号：R782[医药卫生—口腔医学]