银杏达莫注射液联合rt-PA静脉溶栓对急性脑梗死患者神经功能、血液流变学及血清NSE、S100B水平的影响  

Effects of Yinxingdamo Injection Combined with rt-PA Intravenous Thrombolysis on Neurological Function,Hemorheology and Serum NSE,S100B Levels in Patients with Acute Cerebral Infarction

作　　者：郭红玲[1] 欧阳艳红[2] 苏健玲 王圣[4] 黄咏东[5] GUO Hong-ling;OUYANG Yan-hong;SU Jian-ling;WANG Sheng;HUANG Yong-dong(Health Center,Hainan People's Hospital,Haikou,Hainan,570311,China;Department of Emergency Medicine,Hainan People's Hospital,Haikou,Hainan,570311,China;Department of Rehabilitation Medicine,Hainan West Central Hospital,Haikou,Hainan,571700,China;Department of Internal Medicine-Cardiovascular,Hainan People's Hospital,Haikou,Hainan,570311,China;Department of Gastroenterology,Hainan People's Hospital,Haikou,Hainan,570311,China)

机构地区：[1]海南省人民医院保健中心,海南海口570311 [2]海南省人民医院急诊内科,海南海口570311 [3]海南西部中心医院康复医学科,海南海口571700 [4]海南省人民医院心血管内科,海南海口570311 [5]海南省人民医院消化内科,海南海口570311

出　　处：《现代生物医学进展》2020年第18期3577-3581,共5页Progress in Modern Biomedicine

基　　金：海南省自然科学基金项目(812150)。

摘　　要：目的:探讨银杏达莫注射液联合重组人组织型纤溶酶原激活物(rt-PA)静脉溶栓对急性脑梗死患者神经功能、血液流变学及血清神经元特异性烯醇化酶(NSE)、S100B蛋白(S100B)水平的影响。方法:采用随机数字表法将2017年1月-2018年12月本院收治的160例急性脑梗死患者分为两组,对照组(80例)患者接受常规治疗+rt-PA静脉溶栓,研究组(80例)患者接受常规治疗+rt-PA静脉溶栓+银杏达莫注射液。治疗后对比两组患者的近期疗效、美国国立卫生研究院卒中量表(NIHSS)评分、改良RANKIN量表(m RS)评分、血液流变学指标[全血比黏度、血浆比黏度、红细胞比容(HCT)]、NSE、S100B水平的差异。结果:研究组患者的总有效率高于对照组患者(P<0.05);研究组患者治疗后的NIHSS、m RS评分低于对照组患者(P<0.05);研究组患者治疗后的全血比黏度、血浆比黏度、HCT水平低于对照组患者(P<0.05);研究组患者治疗后的的血清NSE、S100B水平低于对照组患者(P<0.05)。治疗期间,两组患者均无明显药物相关不良反应发生。结论:银杏达莫注射液联合rt-PA静脉溶栓治疗的疗效满意,可改善急性脑梗死患者神经功能,优化血液流变学状态,并降低血清NSE、S100B水平,且安全性好。Objective:To investigate the effects of yinxingdamo injection combined with recombinant human tissue plasminogen activator(rt-PA)intravenous thrombolysis on nerve function,hemorheology,serum neuron specific enolization enzyme(NSE),S100 B protein(S100 B)in patients with acute cerebral infarction.Methods:160 patients with acute cerebral infarction admitted to our hospital from January 2017 to December 2018 were divided into two groups by the method of random number table.Patients in control group(80 cases)received conventional treatment and rt-PA intravenous thrombolysis,while those in study group(80 cases)received conventional treatment and rt-PA intravenous thrombolysis and ginkgo biloba injection.Recent efficacy,National Institutes of Health Stroke Scale(NIHSS)score,Modified RANKIN scale(m RS)score,hemorheology indexes[whole blood specific viscosity,ratio of viscosity,hematocrit(HCT)],NSE,S100 B levels difference were compared between two groups after treatment.Results:Total effective rate of study group was higher than that of control group(P<0.05).NIHSS,m RS score were of study group lower than those of control group after treatment(P<0.05).Whole blood specific viscosity,ratio of viscosity,HCT of study group were lower than those of control group after treatment(P<0.05).Serum NSE,S100 B levels of study group were lower than those of control group after treatment(P<0.05).During the treatment,no obvious drug-related adverse reactions occurred in the two groups.Conclusion:Yinxingdamo injection combined with rt-PA intravenous thrombolysis has significant effect on patients with acute cerebral infarction and plays an active role in improving neurological function,optimizing hemorheology and reducing the serum levels of NSE,S100 B in patients with acute cerebral infarction and in good safety.

关 键 词：急性脑梗死 银杏达莫注射液 重组人组织型纤溶酶原激活物 神经功能 

分 类 号：R743[医药卫生—神经病学与精神病学]