2010-2019年167例经局部切除术治疗的睫状体肿物的临床组织病理构成分析  

Clinical histopathologic constituent analysis of 167 cases of ciliary body mass treated by local resection from 2010 to 2019

作　　者：高飞 顼晓琳 张旭 张志豹 魏文斌 Gao Fei;Xu Xiaolin;Zhang Xu;Zhang Zhibao;Wei Wenbin(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing Tongren Hospital,Capital Medical University,Beijing 100005,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科研究所,眼科学与视觉科学北京市重点实验室,眼内肿瘤诊治研究北京市重点实验室,100005

出　　处：《眼科》2020年第5期391-395,共5页Ophthalmology in China

基　　金：国家自然科学基金(81502341);北京市自然科学基金(7151003)。

摘　　要：目的分析局部切除的睫状体肿物的临床组织病理类型构成。设计回顾性病例系列。研究对象2010-2019年北京同仁医院经局部切除术治疗的睫状体肿物167例。方法回顾睫状体肿物的病理记录,包括一般临床信息和病理诊断。分析睫状体肿物的组织病理类型构成比。主要指标组织病理类型构成比。结果167例睫状体肿物中黑色素细胞瘤44例(26.3%),无色素上皮腺瘤/腺癌32/2例(20.4%),黑色素瘤29例(17.4%),神经鞘瘤14例(8.4%),平滑肌瘤12例(7.2%),胶质神经瘤11例(6.6%),髓上皮瘤9例(5.4%),色素上皮腺瘤7例(4.2%),血管瘤2例(1.2%),炎症2例(1.2%),色素痣、淋巴瘤和颗粒细胞病变各1例(0.6%)。其中,恶性病变占24.6%(41/167),良性病变占75.4%(126/167)。睫状体上皮层起源的肿物占36.5%,基质起源的肿物占63.5%;上皮层起源的肿物前三位分别为无色素上皮腺瘤、髓上皮瘤、色素上皮腺瘤;基质起源的肿物前三位分别为黑色素细胞瘤、黑色素瘤、神经鞘瘤。有色素肿物和无色素肿物数量相当(49.7%和50.3%);有色素肿物的前三位分别为黑色素细胞瘤、黑色素瘤和色素上皮腺瘤;无色素肿瘤的前三位分别为无色素上皮腺瘤、神经鞘瘤和平滑肌瘤。结论本研究较大样本的睫状体肿物中占前三位的病理类型是黑色素细胞瘤、无色素上皮腺瘤、黑色素瘤。恶性肿瘤仅占四分之一,提示在选择治疗方案时要优先考虑肿瘤局部切除术。Objective To analyze the clinical histopathologic constituent of 167 cases of ciliary body mass treated by local resection.Design Retrospective case series.Participants 167 ciliary body masses treated by local resection in Beijing Tongren Hospital in 2010-2019.Methods The pathological records of ciliary body masses were reviewed retrospectively to record the general clinical information and pathological diagnosis.The constituent ratio of the histopathologic types of ciliary body masses was calculated.Main Outcome Measures The constituent ratio of the histopathologic types.Results This group of 167 ciliary body masses were arranged in order of constituent ratio:44 cases of melanocytoma(26.3%),32/2 cases of nonpigmented epithelium adenoma/adenocarcinoma(20.4%),29 cases of melanoma(17.4%),14 cases of schwannoma(8.4%),12 cases of leiomyoma(7.2%),11 cases of glioneuroma(6.6%),9 cases of medulloepithelioma(5.4%),7 cases of pigmented epithelium adenoma(4.2%),2 cases of hemangioma(1.2%),2 cases of inflammation(1.2%),nevus,lymphoma and granular cell lesion 1 case(0.6%)each.Malignant lesions accounted for 24.6%(41/167)and benign lesions accounted for 75.4%(126/167).Masses originated from ciliary body epithelial layer accounted for slightly more than a third(36.5%),and masses originated from ciliary body stroma accounted for slightly less than two thirds(63.5%).The top three of epithelial layer originated masses were nonpigmented epithelium adenoma,medulloepithelioma,pigmented epithelium adenoma.The top three of stroma originated masses were melanocytoma,melanoma,and schwannoma.The number of pigmented masses and nonpigmented masses was equal(49.7%and 50.3%).The top three of pigmented masses were melanocytoma,melanoma and pigmented epithelium adenoma.The top three of nonpigmented masses were nonpigmented epithelium adenoma,schwannoma and leiomyoma.Conclusion In this group of ciliary body masses,the top three histopathologic types were melanocytoma,nonpigmented epithelium adenoma and melanoma.On the whole,malignancy accounted

关 键 词：眼肿瘤/病理学 睫状体 

分 类 号：R779.6[医药卫生—眼科]