Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata  

作　　者：Bin Zhou Yan Wu Lishe Gan Seema Dalal Maria B.Cassera Jianmin Yue 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zuchongzhi Road,Shanghai 201203,China [2]College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,China [3]Department of Biochemistry,MC 0308,Virginia Tech,Blacksburg,Virginia 24061,United States [4]Department of Biochemistry and Molecular Biology,and Center for Tropical and Emerging Global Diseases(CTEGD),University of Georgia,Athens,Georgia 30602,United States

出　　处：《Chinese Journal of Chemistry》2020年第8期812-816,共5页中国化学（英文版）

基　　金：The National Natural Science Foundation of china(No.21532007);the Druglnnovation Major Project of China(2018ZX09711001-001-005);the Biological Resources Pro-gram,CAS(KFJ-BRP-O08)of China are gratefully acknowledged.

摘　　要：Securines A—E,three dimeric diarymethane derivatives(1-3)and two enantiomeric diarymethane derivative monomers(4 and 5),were isolated and characterized from the medicinal plant Securidaca inappendiculata.Compounds 1 and 2 are a pair of enantiomeric diarymethane derivative dimers,and compound 3 is a mesomeric diarymethane derivative dimer.Their structures were determined by a combination of spectroscopic data,X-ray crystallography,electronic circular dichroism(ECD)analysis,and computational ECD calculations.Dimeric compounds 1-3 showed moderate antiplasmodial activities with IC50 values of 0.9,1.4,and 1.5μM,respectively.

关 键 词：METHANE DERIVATIVE CIRCULAR 

分 类 号：O62[理学—有机化学]