光动力疗法在口腔黏膜癌变防治中的应用  

Application of photodynamic therapy for oral carcinogenesis prevention

作　　者：何宇晴 但红霞 陈谦明 He Yuqing;Dan Hongxia;Chen Qianming(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&National Key Laboratory of Oral Mucosal Diseases&Innovation Unit of Oral Mucosal Carcinogenesis and Prevention,Chinese Academy of Medical Sciences&Dept,of Oral Medicine,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心,口腔黏膜病国家临床重点专科中国医学科学院口腔黏膜癌变与防治创新单元,四川大学华西口腔医院黏膜病科,成都610041

出　　处：《国际口腔医学杂志》2020年第6期669-676,共8页International Journal of Stomatology

基　　金：国家自然科学基金(81572663)。

摘　　要：口腔黏膜癌变是从正常口腔黏膜发展为口腔黏膜潜在恶性疾患,最终成为口腔癌的过程。通常的治疗目标是在癌变早期进行干预,防止癌变发生,但目前为止缺少疗效确切且安全的治疗方法。光动力疗法是一种基于光敏剂介导的光化学、光生物学反应,对病变细胞产生杀伤作用的治疗手段,在治疗疾病、改善预后等方面具有诸多优点,是口腔黏膜潜在恶性疾患及口腔鳞状细胞癌的一种新的治疗选择。本文主要对光动力疗法及其在口腔黏膜癌变防治中的应用进行综述。Oral carcinogenesis starts from the oral mucosa to oral potentially malignant disorder(OPMD)and eventually leads to oral cancer.Substantial effort has been directed to prevent oral carcinogenesis at its early stage;however,success is elusive.Photodynamic therapy is based on photosensitiser-mediated photochemical and photobiological effects leading to cellular damage in lesional tissues.This technique is a new treatment option for OPMD and oral squamous cell carcinoma.This article reviewed the application of photodynamic therapy for oral carcinogenesis prevention.

关 键 词：光动力疗法 口腔黏膜潜在恶性疾患 口腔鳞状细胞癌 光敏剂 

分 类 号：R781.5[医药卫生—口腔医学]