非药物预处理对脑缺血后兴奋毒性的调控作用  

Regulatory Effect of Non-Pharmaceutical Preconditioning on Excitotoxicity after Cerebral Ischemia

作　　者：张宝瑜 李礼[1,2,3,4] 王冠然 宁文华 王洋 赵梦雄[1] 王舒 ZHANG Baoyu;LI Li;WANG Guanran;NING Wenhua;WANG Yang;ZHAO Mengxiong;WANG Shu(The First Teaching Hospital of Tianjin University of Tratitional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine,Tianjin 300381,China;Tianjin Key Laboratory of Acupuncture and Moxibustion,Tianjin 300381,China;Heilongjiang University of Chinese Medicine,Harlbin 150040,Heilongjiang,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381 [3]国家中医药管理局脑病针刺疗法重点研究室,天津300381 [4]天津市针灸学重点实验室,天津300381 [5]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中华中医药学刊》2020年第9期173-176,I0030,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81804189);天津市教委项目(2018KJ020);天津市卫生和计划生育委员会中医、中西医结合科研专项项目(2017130);天津市科技计划项目(16ZXMJSY00040)。

摘　　要：兴奋性神经递质谷氨酸过量释放引起的神经毒性是脑缺血后一系列级联事件发生的主要初始病理变化。非药物预处理可通过抑制缺血后兴奋毒性减轻神经损伤。将首先梳理脑区谷氨酸代谢过程,包括谷氨酸突触前生成和释放、突触间隙重摄取以及突触后与受体结合;然后围绕谷氨酸代谢过程中的作用位点对非药物预处理在兴奋毒性方面的研究进展进行概述,为进一步研究非药物预处理对抗脑缺血后兴奋性氨基酸毒性的作用机制提供参考。Neurotoxicity caused by the excessive release of the excitatory neurotransmitter glutamate is the main initial pathological change in a series of cascade events after cerebral ischemia.Non-pharmaceutical preconditioning can reduce ischemia-induced cerebral injury by inhibiting excitatory toxicity.This paperfirst reviewed the glutamate metabolism in brain regions,including presynaptic glutamate production and release,synaptic gap reuptakeand postsynaptic binding to receptors.And then,wesummarized the research progress of non-pharmaceutical pretreatmentin regulating excitotoxicity from progress of glutamate metabolism.Hopefully,our work could provide reference for further research on the mechanism of non-pharmaceutical pretreatment in inhibiting excitotoxicity of ischemic stroke.

关 键 词：脑缺血耐受性 谷氨酸兴奋毒性 缺血预处理 运动预处理 电针预处理 

分 类 号：R743[医药卫生—神经病学与精神病学]