一种合成4,5-二甲氧基-2-硝基苄氯的新方法  

A novel method for the synthesis of 1(chloromethyl)-4,5-dimethoxy-2-nitrobenzene

作　　者：吕瑞东 LV Ruidong(Shanxi Lu'an Coal-based Clean Energy Co.,Ltd.,Changzhi Shanxi 046200,China)

机构地区：[1]潞安煤基清洁能源有限责任公司,山西长治046200

出　　处：《山西化工》2020年第5期31-33,共3页Shanxi Chemical Industry

摘　　要：以3,4-二甲氧基苯甲醛为原料,经硝化、还原、氯化合成了4,5-二甲氧基-2-硝基苄氯。用双(三氯甲基)碳酸酯代替五氯化磷或氯化亚砜作为氯源是该合成方法的主要特点。通过核磁共振氢谱、核磁共振碳谱对产物的结构进行了表征。该方法总产率为51%。该合成方法反应条件温和且无需色谱纯化,为工业生产提供了指导。1-(chloromethyl)-4,5-dimethoxy-2-nitrobenzene was synthesized from 3,4-dimethoxybenzaldehyde via nitration,reduction and chlorination.Instead of using phosphorus pentachloride or sulfoxide chloride as chlorine source,chlorination by the use of bis(trichloromethyl)carbonate is the main highlight of this synthetic method.The structure of product was characterized by 1H NMR spectra and 13C NMR spectra.The total yield was 51%.The synthetic method has mild reaction conditions and no need of chromatographic purification,which provides guidance for industrial manufacture.

关 键 词：合成方法 双(三氯甲基)碳酸酯 4 5-二甲氧基-2-硝基苄氯 

分 类 号：O62[理学—有机化学]