奥沙利铂联合卡培他滨治疗晚期结直肠癌的疗效观察  

Efficacy of oxaliplatin combined with capecitabine in the treatment of advanced colorectal cancer

作　　者：孟宪禄[1] MENG Xianlu(Department of Oncology,Mianchi County People's Hospital,Mianchi 472400,China)

机构地区：[1]渑池县人民医院肿瘤科,河南渑池472400

出　　处：《肿瘤基础与临床》2020年第3期195-197,共3页journal of basic and clinical oncology

摘　　要：目的探讨晚期结直肠癌患者采用卡培他滨联合奥沙利铂治疗的临床疗效。方法纳入2016年12月至2017年12月渑池县人民医院收治的晚期结直肠癌患者110例,随机均分为2组。常规组采用卡培他滨治疗,研究组在此基础上联合奥沙利铂治疗。比较2组的治疗总有效率、1 a生存率、生活质量。结果研究组治疗后KPS评分、治疗总有效率、1 a生存率分别为(85.6±5.8)分、89.1%、76.4%,均明显高于常规组的(74.4±6.3)分、74.5%、56.4%;ZPS评分为(0.9±0.1)分,明显低于常规组的(1.2±0.4)分;差异均有统计学意义(t=9.700,P<0.001;χ^2=3.911,P=0.048;χ^2=4.928,P=0.026;t=5.396,P<0.001)。结论晚期结直肠癌患者采用卡培他滨联合治疗,能明显提高其临床疗效与生活质量,改善患者生存状况。Objective To explore the clinical efficacy of capecitabine combined with oxaliplatin in the treatment of patients with advanced colorectal cancer.Methods The 110 patients with advanced colorectal cancer in the Mianchi County People's Hospital from December 2016 to December 2017 were divided into two groups randomly.The 55 patients in the conventional group were treated with capecitabine,and the 55 patients in the research group were treated with oxaliplatin combined with capecitabine.The total effective rate,1-year survival rate and quality of life of the two groups were compared.Results After treatment,the KPS score,the total effective rate and 1-year survival rate of the research group[(85.6±5.8)scores,89.1%,76.4%]were significantly higher than those of the conventional group[(74.4±6.3)scores,74.5%,56.4%],and the ZPS score of the research grouop[(0.9±0.1)scores]was significantly lower than that of the conventional group[(1.2±0.4)scores],the differences between the two groups were statistically significant(t=9.700,P<0.001;χ^2=3.911,P=0.048;χ^2=4.928,P=0.026;t=5.396,P<0.001).Conclusion Capecitabine combined with oxaliplatin in the treatment of patients with advanced colorectal cancer can significantly improve the clinical efficacy and quality of life,and prolong the survival.

关 键 词：晚期结直肠癌 奥沙利铂 卡培他滨 疗效 生活质量 

分 类 号：R735.3[医药卫生—肿瘤]