大黄灵仙胶囊调控小鼠胆囊运动功能预防胆囊结石的机制研究  

Mechanism of Dahuang Lingxian capsule regulating the gallbladder motor function to prevent gallstone in mice

作　　者：卓臣义[1] 周洋 冯时 包崇婵 姜艳[3] 唐乾利[3] Zhuo Chenyi;Zhou Yang;Feng Shi;Bao Chongchan;Jiang Yan;Tang Qianli(Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Graduate School,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院,广西百色533000 [2]右江民族医学院研究生学院,广西百色533000 [3]右江民族医学院,广西百色533000

出　　处：《右江民族医学院学报》2020年第5期539-542,共4页Journal of Youjiang Medical University for Nationalities

基　　金：国家自然科学基金项目(81860851);2017年广西科学研究与技术开发计划项目(重点研发计划)(桂科AB17195071);广西自然科学基金重点项目(2018GXNSFDA281017);2017年广西科学研究与技术开发计划项目(广西科技基地和人才专项)(桂科AD17129025);2019年广西研究生创新项目(YCSW2019217)。

摘　　要：目的探究大黄灵仙胶囊对小鼠胆囊运动功能的影响。方法将48只SPF级C57BL/6雄性小鼠按随机数字表法随机分成4组,分别为:普食组(P组)、模型组(M组)、大黄灵仙胶囊组(ZD组)、熊去氧胆酸组(ZX组),每组各12只。P组予以普通饲料喂养,其余3组均以致石性饲料喂养,各组正常饮水;ZD组及ZX组予以药物干预,造模8周后,测量各组小鼠胆囊体积,评估各组小鼠胆囊运动功能。结果ZD组、ZX组小鼠胆囊体积明显小于M组(P<0.05),ZD组与ZX组的胆囊体积大小差异无统计学意义(P>0.05)。结论大黄灵仙胶囊可通过调控胆囊体积改善小鼠胆囊排空功能,这可能是其预防胆囊结石形成的部分机制。Objective To explore the effect of Dahuang Lingxian capsule on gallbladder motor function in mice.Methods Forty-eight SPF C57 BL/6 male mice were randomly divided into 4 groups according to the random number table method:general food group(group P),model group(group M),Dahuang Lingxian capsule group(group ZD),ursodesoxycholic acid group(group ZX),with 12 mice in each group.Group P was fed with common feed,while the other three groups were fed with lithogenic feed.Mice in each group were given water normally.Group ZD and group ZX were intervened with medicine.After 8 weeks of modeling,the gallbladder volume of mice in each group was measured,and the gallbladder motor function of mice in each group was evaluated.Results The gallbladder volume of mice in group ZD and group ZX was significantly smaller than that of group M(P<0.05),and there was no significant difference in gallbladder volume of mice between group ZD and group ZX(P>0.05).Conclusion Dahuang Lingxian capsule can improve gallbladder emptying function by regulating the volume of gallbladder,which may be part of its mechanism to prevent gallstone formation.

关 键 词：胆石 胆囊运动 大黄灵仙胶囊 

分 类 号：R575.621[医药卫生—消化系统]