胸腔镜单孔手术对原发性非小细胞肺癌炎性反应的效果观察  

The effect of single-port thoracoscopic surgery on the inflammatory response of primary non-small cell lung cancer

作　　者：赖鸿章[1] 文习武 温树权 张玉平 吴锡龙 彭玉坤 吴询 LAI Hong-zhang;WEN Xi-wu;WEN Shu-quan(Department of Thoracic Surgery,Donghua Hospital,Dongguan 523000,China)

机构地区：[1]东莞东华医院胸外科,523000

出　　处：《中国实用医药》2020年第28期1-4,共4页China Practical Medicine

基　　金：胸腔镜单孔手术对原发性非小细胞肺癌炎性反应的效果观察(项目编号:201950715046846)。

摘　　要：目的探讨胸腔镜单孔手术对原发性非小细胞肺癌炎性反应的效果。方法60例原发性非小细胞肺癌患者,根据随机数字表法分为观察组和对照组,各30例。观察组给予胸腔镜单孔手术治疗,对照组患者行常规开胸手术治疗。比较两组患者手术情况[手术时间、术中出血量、淋巴结清扫个数、术后置管时间、术后72 h引流量、术后杜冷丁使用量、术后住院时间、术后72 h视觉模拟评分法(VAS)评分、住院费用]以及治疗前后炎性因子指标[C反应蛋白(CRP)、白细胞介素(IL)-6、IL-10、肿瘤坏死因子-α(TNF-α)]。结果观察组术中出血量(115.97±21.44)ml、术后72 h引流量(261.47±28.41)ml、术后杜冷丁使用量(204.78±12.24)mg少于对照组的(333.18±25.77)ml、(399.57±27.19)ml、(259.18±13.58)mg,术后置管时间(3.58±0.33)d、术后住院时间(10.11±2.34)d短于对照组的(5.74±0.67)、(14.27±1.89)d,术后72 hVAS评分(2.18±0.33)分低于对照组的(5.71±0.58)分,住院费用(28419.37±2456.18)元少于对照组的(37159.22±2784.51)元,差异均具有统计学意义(P<0.05)。两组手术时间、淋巴结清扫个数比较,差异无统计学意义(P>0.05)。治疗后,两组患者CRP、IL-6、IL-10、TNF-α水平均低于治疗前,且观察组CRP(7.08±1.01)mg/L、IL-6(8.97±1.05)pg/ml、IL-10(100.27±20.15)pg/ml、TNF-α(1.06±0.08)ng/ml低于对照组的(8.04±1.03)mg/L、(21.34±3.98)pg/ml、(135.49±23.18)pg/ml、(1.31±0.11)ng/ml,差异均具有统计学意义(P<0.05)。结论胸腔镜单孔手术对原发性非小细胞肺癌患者的疗效较好,能够减少患者的术中出血量、术后72 h引流量、术后杜冷丁使用量,缩短患者的术后置管时间、术后住院时间,减轻患者的术后72 hVAS评分,降低住院费用,改善患者的CRP、IL-6、IL-10和TNF-α水平。Objective To investigate the effect of single-port thoracoscopic surgery on the inflammatory response of primary non-small cell lung cancer.Methods A total of 60 patients with primary non-small cell lung cancer were divided into observation group and control group according to random numerical table,with 30 cases in each group.The observation group was treated with single-port thoracoscopic surgery,and the control group was treated with conventional thoracotomy.The operation status[operation time,amount of intraoperative hemorrhage,number of lymph node dissection,postoperative catheterization time,drainage volume at 72 h after operation,postoperative dose of dolantin,postoperative hospitalization time,postoperative visual analogue scale(VAS)score,hospitalization expenses],inflammatory indicators[C-reactive protein(CRP),interleukin(IL)-6,IL-10,tumor necrosis factor-α(TNF-α)]before and after treatment were compared between the two groups.Results The amount of intraoperative hemorrhage(115.97±21.44)ml,drainage volume at 72 h after operation(261.47±28.41)ml,postoperative dose of dolantin(204.78±12.24)mg of the observation group were less than(333.18±25.77)ml,(399.57±27.19)ml and(259.18±13.58)mg of the control group,postoperative catheterization time(3.58±0.33)d,postoperative hospitalization time(10.11±2.34)d were shorter than(5.74±0.67)and(14.27±1.89)d of the control group,VAS score 72 h after operation(2.18±0.33)points was lower than(5.71±0.58)points of the control group,and hospitalization expenses(28419.37±2456.18)yuan was less than(37159.22±2784.51)yuan of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in operation time and number of lymph node dissection between the two groups(P>0.05).After treatment,CRP,IL-6,IL-10 and TNF-αof the two groups were lower than those before treatment,and CRP(7.08±1.01)mg/L,IL-6(8.97±1.05)pg/ml,IL-10(100.27±20.15)pg/ml and TNF-α(1.06±0.08)ng/ml of the observation group were lower than(

关 键 词：胸腔镜单孔手术 原发性非小细胞肺癌 炎性反应 效果 

分 类 号：R734.2[医药卫生—肿瘤]