莫沙必利对缓解胃食管反流病的临床症状及对患者远期生活质量的影响探讨  

Effect of mosapride on relieving clinical symptoms and long-term quality of life of patients with gastroesophageal reflux disease

作　　者：章泽鑫 林贵德 曾彬 ZHANG Ze-xin;LIN Gui-de;ZENG Bin(Department of Emergency Internal Medicine,Longgang District Second People’s Hospital,Shenzhen 518112,China)

机构地区：[1]深圳市龙岗区第二人民医院急诊内科,518112 [2]深圳市龙岗区第二人民医院消化内镜诊疗科,518112 [3]深圳市龙岗区第二人民医院内二科,518112

出　　处：《中国实用医药》2020年第28期105-107,共3页China Practical Medicine

摘　　要：目的探讨莫沙必利对缓解胃食管反流病(GERD)的临床症状及改善患者生活质量的临床效果。方法100例胃食管反流病患者作为研究对象,根据治疗方案不同分为研究组(53例)和对照组(47例)。研究组采用枸椽酸莫沙必利治疗,对照组接受泮托拉唑治疗。比较两组治疗效果、症状积分及生活质量。结果研究组患者的治疗总有效率为96.23%,高于对照组的82.98%,差异有统计学意义(P<0.05)。研究组治疗8周后,胸骨后疼痛积分、反酸积分、烧心的症状积分分别为(0.62±0.19)、(0.95±0.21)、(0.92±0.33)分,均低于对照组的(0.90±0.08)、(1.09±0.33)、(1.06±0.24)分,差异有统计学意义(P<0.05)。研究组生理功能、生理职能、躯体疼痛、精力和总体健康均高于对照组,差异有统计学意义(P<0.05);两组精神健康、情感职能、社会功能评分比较,差异无统计学意义(P>0.05)。结论莫沙必利治疗胃食管反流病整体效果良好,可作为首选方案应用于临床。Objective To discuss the clinical effect of mosapride on relieving clinical symptoms and long-term quality of life of patients with gastroesophageal reflux disease(GERD).Methods A total of 100 patients with gastroesophageal reflux disease as study subjects were divided into research group(53 cases)and control group(47 cases).The research group was treated with mosapride citrate,and the control group was treated with pantoprazole.The therapeutic effect,symptom integral and quality of life were compared between the two groups.Results The total effective rate of treatment of the research group was 96.23%,which was higher than 82.98%of the control group,and the difference was statistically significant(P<0.05).8 weeks after treatment,the symptom scores for post-sternal pain,acid reflux and heartburn of the research group were(0.62±0.19),(0.95±0.21)and(0.92±0.33)points,which were all lower than(0.90±0.08),(1.09±0.33)and(1.06±0.24)points of the control group,and the difference was statistically significant(P<0.05).The physiological function,physiological limitations,physical pain,energy and overall health score of the research group were all higher than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in mental health,emotional function and social function score between the two groups(P>0.05).Conclusion Mosapride has a good overall effect in the treatment of gastroesophageal reflux disease,and can be used as the preferred choice for clinical application.

关 键 词：胃食管反流病 莫沙必利 泮托拉唑 临床症状 生活质量 

分 类 号：R57[医药卫生—消化系统]